Evidence map›Paper›PMID 40210383›Full record

ReviewNeuroimaging clinics of North America2025

Altered Clearance in Alzheimer's Disease and Cerebral Amyloid Angiopathy.

Soheil Mohammadi, Mahsa Dolatshahi, Farzaneh Rahmani, Cyrus A Raji

Abstract readReview
In one paragraph

Review in Neuroimaging clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Soheil MohammadiMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.
Mahsa DolatshahiMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.
Farzaneh RahmaniMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA.
Cyrus A RajiMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA; Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: craji@wustl.edu.

Funding

The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1M
Longitudinal validation of retinal biomarkers against cerebral imaging in preclinical Alzheimer's diseaseR01AG079241 · NIA · UNIVERSITY OF RHODE ISLAND · PI Jessica Alber · 2022 to 2026
$10.4M
Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife ObesityRF1AG072637 · NIA · WASHINGTON UNIVERSITY · PI RAJI, CYRUS A · 2021 to 2021
$2.3M
Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife ObesityR01AG072637 · NIA · WASHINGTON UNIVERSITY · PI RAJI, CYRUS A · 2024 to 2025
$1.4M
NIA NIH HHS R01 AG070883NIA NIH HHS R01 AG072637NIA NIH HHS R01 AG079241NIA NIH HHS RF1 AG072637
6 · The paper itself

Abstract

With our focus on Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), the authors herein provided a comprehensive overview of impaired amyloid beta and tau clearance pathways observed through advanced neuroimaging techniques such as dynamic contrast-enhanced MR imaging, arterial spin labeling, phase contrast MR imaging, PET, and functional MR imaging. The findings suggest the role of impaired degradation clearance, blood-brain barrier clearance, perivascular clearance, glymphatic system clearance, and cerebrospinal fluid dynamics in AD and CAA pathogenesis.

Indexed as

Alzheimer DiseaseCerebral Amyloid AngiopathyMagnetic Resonance ImagingNeuroimagingAmyloid beta-PeptidesBrainHumansPositron-Emission TomographyAmyloid beta-PeptidesAlzheimer’s diseaseAmyloidBlood-brain barrier clearanceCerebral amyloid angiopathyCerebrospinal fluid clearanceDegradation clearanceGlymphatic clearancePerivascular clearance

Identifiers

PMID40210383
PMCPMC12227102

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.