Evidence mapPaperPMID 40210592Full record

ReviewNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2025

Maintaining kidney health in aging societies: a JSN and ERA call to action.

Alberto Ortiz, Anneke Kramer, Ivan Rychlík, Masaomi Nangaku, Motoko Yanagita, Kitty J Jager, Fergus J Caskey, Vianda S Stel, Naoki Kashihara, Takahiro Kuragano and 7 more

Abstract readReview
In one paragraph

Review in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. ERA's ABCDE framework for kidney disease prevention: turning the WHO kidney health resolution into action.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  7. Review
  8. Review
  9. Impact of switching from the CKD-EPIClinical kidney journal · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alberto OrtizDepartment of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.ORCID 0000-0002-9805-9523
Anneke KramerERA Registry, Department of Medical Informatics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-7560-2669
Ivan RychlíkDepartment of Medicine, Third Faculty of Medicine, Charles University, Prague, and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Masaomi NangakuDivision of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0001-7401-2934
Motoko YanagitaDepartment of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-0339-9008
Kitty J JagerERA Registry, Department of Medical Informatics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-0444-8569
Fergus J CaskeyPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Vianda S StelERA Registry, Department of Medical Informatics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-0007-1947
Naoki KashiharaKawasaki Medical School, Kurashiki, Japan.
Takahiro KuraganoDivision of Kidney, Dialysis and Cardiology, Department of Internal Medicine, Hyogo Medical University, Hyogo, Japan.ORCID 0000-0001-6453-3824
Yusuke SuzukiDepartment of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Yoshiaki TakemotoDepartment of Urology, Osaka Metropolitan University, Osaka, Japan.
Hideki YokoiDepartment of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.ORCID 0000-0001-8343-9737
Giuseppe PalladinoEuropean Renal Association, Parma, Italy.
Danilo FliserUniversität des Saarlandes, Homburg, Germany.
Roser TorraNephrology Department, Fundació Puigvert, Institut de Recerca Sant Pau (IR-Sant Pau), Departament de Medicina, Universitat Autònoma de Barcelona, RICORS2040, Barcelona, Spain.ORCID 0000-0001-8714-2332
Christoph WannerDepartment of Clinical Studies and Epidemiology, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0001-9507-5301

Funding

Comunidad de Madrid en Biomedicina P2022/BMD-7223COST CA21165European Union 101101220European Union 101137054European Union 101168626European Union HLTH-2023-CARE-04European Union HORIZON-MSCA-2023-DN-01-01European Union PMP21/00109Instituto de Salud Carlos III AC22/00027Instituto de Salud Carlos III ERA-PerMed-JTC2022Instituto de Salud Carlos III PI21/00251Instituto de Salud Carlos III PI22/00050Instituto de Salud Carlos III PI22/00469Instituto de Salud Carlos III RD21/0005/0001
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in the death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socio-economic and environmental burdens and the need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying biological kidney aging will contribute to healthy aging, as the kidneys have gerosuppressor functions and CKD has the highest negative impact on body aging among chronic non-communicable diseases. This action should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular-kidney-metabolic health, geromedicine, gerosuppressors and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology and European Renal Association call to action on Achieving Kidney Health in Aging/Aged Societies.

Indexed as

AgingKidneyRenal Insufficiency, ChronicAgedHumansSocieties, Medicalagingchronic kidney diseasegerosuppressionkidney agingkidney replacement therapy

Identifiers

PMID40210592
PMCPMC12315803

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.