Evidence map›Paper›PMID 40210821›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

The role of glycemic control and symptoms and symptom clusters in breast cancer survivors with type 2 diabetes.

Susan Storey, Xiao Luo, Susan Ofner, Susan M Perkins, Diane Von Ah

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Susan StoreyIndiana University School of Nursing, Indianapolis, IN, 46260, USA. sustorey@iu.edu.ORCID http://orcid.org/0000-0003-0701-7465
Xiao LuoDepartment of Management Science and Information Systems, School of Business, Oklahoma State University, Stillwater, OK, USA.ORCID http://orcid.org/0000-0002-3649-9785
Susan OfnerDepartment of Biostatistics and Health Data Science, School of Medicine and Richard M. Fairbanks School of Public Health, Indiana University, 410 W 10 th Street, Suite 3000, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0001-8107-7859
Susan M PerkinsDepartment of Biostatistics and Health Data Science, School of Medicine and Richard M. Fairbanks School of Public Health, Indiana University, 410 W 10 th Street, Suite 3000, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0002-5842-4354
Diane Von AhCancer Research, Center for Healthy Aging, Self-Management and Complex Care, College of Nursing, The Ohio State University (OSU), 394 Newton Hall, 1585 Neil Avenue, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0002-3189-1307

Funding

Tumor Microenvironment and MetastasisP30CA082709 · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · 1999 to 2025
$10.9M
NCI NIH HHS P30 CA082709
6 · The paper itself

Abstract

purposeThe purpose of the study was to describe the type and number of symptoms and examine symptom clusters of breast cancer survivors (BCS) with diabetes (type 2) by glycemic control (HbA1c < 7 or ≥ 7%).

methodsA retrospective cohort study was conducted. Symptom data were extracted from clinical notes in the electronic health record. BCS (stage I-III) diagnosed between 2007 and 2019 had diabetes, and at least one HbA1c within 8 months of initial chemotherapy was included. Zero-inflated negative binomial regression analysis was used to examine total symptoms by glycemic control. Exploratory factor analysis was conducted to identify symptom clusters.

resultsThree hundred twenty-seven BCS met the inclusion criteria. Two symptom clusters were identified in BCS with HbA1c ≥ 7%: a psychoneurological cluster (anxiety, fatigue, peripheral neuropathy, and depression) and a gastrointestinal cluster (vomiting, nausea, and constipation). Two symptom clusters were identified in BCS with HbA1c < 7% a mixed gastrointestinal/psychoneurological cluster (vomiting, nausea, peripheral neuropathy, fatigue, and constipation) and a mental health symptom cluster (depression and anxiety).

conclusionThe symptom clusters of BCS differed by glycemic control. Prospective research studies are needed to examine the role of glycemic control in symptoms in BCS with diabetes. Understanding the influence of glycemic control can help providers identify BCS at high risk for troublesome symptoms and symptom clusters, thereby facilitating interventions that target glycemic control, potentially mitigating symptoms, and symptom clusters, and improving outcomes for BCS with diabetes.

Indexed as

Breast NeoplasmsCancer SurvivorsDiabetes Mellitus, Type 2Glycemic ControlAdultAgedAnxietyDepressionFatigueFemaleGlycated HemoglobinHumansMiddle AgedRetrospective StudiesGlycated Hemoglobinhemoglobin A1c protein, humanBCSGlycemic controlType 2 diabetes

Identifiers

PMID40210821
PMCPMC11985596

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.