Evidence map›Paper›PMID 40211177›Full record

Observational studyBMC psychiatry2025

Bipolar disorder at mixed states and major depressive disorder with mixed features differ in peripheral biochemical parameters.

Xiaohui Wu, Shuo Wang, Zhiang Niu, Yuncheng Zhu, Ping Sun, Wenxi Sun, Jun Chen, Yiru Fang

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03949218 (Bipolar Disorder and Oxidative Stress Injury Mechanism - Clinical Big Data Analysis Based on Machine Learning), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03949218 completednot on this map

Bipolar Disorder and Oxidative Stress Injury Mechanism - Clinical Big Data Analysis Based on Machine Learning

TypeobservationalSponsorShanghai Mental Health CenterRan2018 to 2018Enrolled3,702ConditionsBipolar Disorder
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaohui Wu *Department of Psychiatry & Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Shuo Wang *Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Zhiang NiuDepartment of Mental Health Center, West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu, 610041, China.
Yuncheng ZhuDivision of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, 200083, China.
Ping SunQingdao Mental Health Center, Qingdao, 266034, China.
Wenxi SunSuzhou Guangji Hospital, Suzhou, 215137, China.
Jun ChenClinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Yiru FangDepartment of Psychiatry & Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yirufang@aliyun.com.

Funding

National Natural Science Foundation of China 81930033the Shanghai Mental Health Centre Clinical Research Center Project CRC2018DSJ01-1, SHDC2020CR6023, CRC2021DX01
6 · The paper itself

Abstract

backgroundLittle is known about the peripheral biochemicals between bipolar disorder at mixed episodes (BDM) and major depressive disorder with mixed features (MDM). This retrospective study was aimed to compare the peripheral biochemical parameters between patients with BDM and MDM.

methodsThis study included data from 269 BDM patients and 86 MDM patients. Biochemical markers covering immune-inflammatory, liver function, metabolic, and thyroid hormone indices were analyzed. Logistic regression models were employed to evaluate associations between biochemical markers and diagnosis. Network analysis and Principal Component Analysis (PCA) was also performed to investigate the relationships among these parameters.

resultsBDM patients had higher neutrophil percentage (NEUT%), white blood cell count (WBC), free triiodothyronine (FT3) and free thyroxine (FT4), while MDM patients exhibited higher levels of C-reactive protein (CRP), direct bilirubin (DBIL) and prealbumin (PA). NEUT%, WBC, FT3 and FT4 showed positive association with the diagnosis of BDM, while PA and DBIL displayed negative correlation with BDM. No significant differences in either network structure or global strength were found between BDM and MDM groups.

conclusionPeripheral biochemical markers, particularly those related to the immune-inflammatory factors and thyroid hormones, differ between BDM and MDM, which could contribute to better understanding of potential status mechanism under the disorders.

trial registrationInternational Clinical Trials Registry Platform: NCT03949218. Registered on 13/05/2019.

Indexed as

Bipolar DisorderMajor Depressive DisorderManiaAdultBilirubinBiomarkersC-Reactive ProteinFemaleHumansLeukocyte CountMaleMiddle AgedPrealbuminRetrospective StudiesThyroid HormonesTriiodothyronineBilirubinBiomarkersC-Reactive ProteinPrealbuminThyroid HormonesTriiodothyronineBiochemicalsBipolar disorderMajor depressive disorderMixed featurePeripheral markers

Identifiers

PMID40211177
PMCPMC11987313

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.