ArticleLipids in health and disease2025
Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Alpha-klotho, insulin resistance, and adiposity among older adults.Journal of the Endocrine Society · 2026Article
- Body roundness index and mortality risk in chronic diseases: a national prospective longitudinal study in China.Aging clinical and experimental research · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a global health issue which has been widely accepted as an aging related pathogenesis. α-Klotho is a protein involved in aging process, mineral metabolism, insulin sensitivity, and the pathogenesis of various age-related diseases. Adiposity correlates with lower soluble α-Klotho, but the role of fat distribution and inflammation remains unclear. The body roundness index (BRI) refines central adiposity assessment beyond BMI. Herein, We aimed to investigate the relationship of BRI, inflammation and serum level of soluble α-Klotho.
methodsWe conducted a cross-sectional analysis of 9,958 U.S. adults (40-79 years) from the 2007-2016 NHANES. We examined association between BRI and serum α-Klotho (SαKl) levels, controlling for demographic, socioeconomic, lifestyle, and clinical factors. We also assessed whether inflammatory markers mediated the BRI-SαKl relationship.
resultsBRI was inversely associated with SαKl levels (P < 0.05). A significant sex interaction was found (P < 0.001), while BRI was positively correlated with multiple proinflammatory markers, which were all inversely related to SαKl levels. Mediation analyses showed inflammatory markers accounted for 20.5% (WBC), 18.0% (neutrophils), and 12.3% (platelets) of the BRI-SαKl association.
conclusionMore severe central adiposity measured by BRI was related to lower SαKl, which may partly be attributed to inflammation. These findings underscore the importance of fat distribution and inflammation in obesity-related aging and may guide interventions to preserve SαKl levels. Longitudinal studies are needed to confirm causality and inform future strategies.
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