Evidence map›Paper›PMID 40211698›Full record

ReviewOncology reports2025

Multiple roles of S100P in pan carcinoma: Biological functions and mechanisms (Review).

Xinlong Wang, Dong Zhao, Ershu Zhao, Yanan Ge, Fei Cai, Yidan Xi, Jiatong Li, Xuefei Liu, Zhendong Zheng

Abstract readReview
In one paragraph

Review in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. [Expression of S100P in Lung Adenocarcinoma and Its Clinical Significance].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinlong Wang *Department of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Dong Zhao *Department of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Ershu ZhaoDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Yanan GeDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Fei CaiDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Yidan XiDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Jiatong LiDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong 510000, P.R. China.
Xuefei LiuDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.
Zhendong ZhengDepartment of Oncology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article examines the multifaceted roles of the S100P gene in pan‑cancer, with the aim of exploring its biological functions and related mechanisms in depth. S100P is a small calcium‑binding protein that recent studies have identified as playing a significant role in the occurrence and progression of various cancers. As research on cancer biomarkers advances, the relationship between S100P expression levels and cancer prognosis, metastasis and invasiveness has garnered increasing attention. However, the specific mechanisms underlying the role of S100P in different cancer types remain elusive and related research is still in the exploratory phase. Therefore, this review systematically summarizes the biological functions of S100P, clarifying its signaling pathways and regulatory mechanisms. This work provides new insights and strategies for targeted therapy and establishes a theoretical basis for subsequent clinical applications. Through this summary, the present review aims to enhance personalized treatment approaches for S100P‑related cancers and strengthen future explorations of S100P.

Indexed as

Biomarkers, TumorCalcium-Binding ProteinsNeoplasm ProteinsNeoplasmsGene Expression Regulation, NeoplasticHumansPrognosisSignal TransductionBiomarkers, TumorCalcium-Binding ProteinsNeoplasm ProteinsS100P protein, humancancerdiagnosismolecular mechanismS100Psignaling pathwaytherapy

Identifiers

PMID40211698
PMCPMC12012437

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.