Comparison of diagnostic accuracy of electrocardiogram-based versus photoplethysmography-based smartwatches for atrial fibrillation detection: A Systematic Review and Meta-Analysis.

Background: Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, significantly affects morbidity and mortality, making early detection crucial for preventing stroke and heart failure. Recent advancements in wearable technology have introduced smartwatches as potential tools for continuous non-invasive AF detection. Objective: This systematic review and meta-analysis aimed to evaluate and compare the diagnostic accuracy of electrocardiography (ECG)-and photoplethysmography (PPG)-based smartwatches in detecting AF. Methodology: A comprehensive search was conducted on PubMed, Google Scholar, and other databases from 18 August to 23 September 2024, to fetch original studies that evaluated performance metrics of ECG and PPG smartwatches in AF detection. The obtained literature was screened according to preset inclusion and exclusion criteria. For included studies, the random-effects model was used to calculate their pooled sensitivity and specificity in AF detection using Jamovi 2.3.28 software. A significance threshold of Results: Out of the 2564 studies screened, 25 met the inclusion criteria: 11 on PPG and 14 on ECG smartwatches. PPG smartwatches exhibited higher diagnostic performance with a pooled sensitivity of 97.4% (95% CI: 96.5-98.3) and specificity of 96.6% (95% CI: 94.9-98.3). Conversely, ECG smartwatches showed a pooled sensitivity of 83% (95% CI: 78-88) and specificity of 88.4% (95% CI: 84.5-92.2), lower than PPG smartwatches. Conclusion: PPG-based smartwatches outperformed ECG-based devices in AF detection, offering higher sensitivity and specificity. Even though both modalities are effective in AF detection, the considerable variability in ECG smartwatch performance highlights the need for further research and standardization.