Evidence map›Paper›PMID 40212360›Full record

ArticleSmall science2024

Structural Effect of Rhenium- and Iridium-Complex Liposome Composition on Their Selectivity for Antimicrobial Photodynamic Therapy.

Giulia Kassab, Neha Manav, Layla Pires, Miffy H Y Cheng, Yulin Mo, Hilde H Buzzá, Iti Gupta, Juan Chen, Gang Zheng

Abstract read
In one paragraph

Article in Small science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Recent Advances in Nanoparticle-Mediated Antibacterial Photodynamic Therapy.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giulia KassabPrincess Margaret Cancer Centre University Health Network Toronto M5G 1L7 Canada.
Neha ManavDepartment of Medical Biophysics University of Toronto Toronto M5G 1L7 Canada.
Layla PiresPrincess Margaret Cancer Centre University Health Network Toronto M5G 1L7 Canada.
Miffy H Y ChengPrincess Margaret Cancer Centre University Health Network Toronto M5G 1L7 Canada.
Yulin MoPrincess Margaret Cancer Centre University Health Network Toronto M5G 1L7 Canada.
Hilde H BuzzáInstitute of Physics Pontificia Universidad Católica de Chile 7820436 Santiago Chile.
Iti GuptaDepartment of Chemistry Indian Institute of Technology Gandhinagar Gandhinagar 382355 Gujarat India.
Juan ChenPrincess Margaret Cancer Centre University Health Network Toronto M5G 1L7 Canada.
Gang ZhengPrincess Margaret Cancer Centre University Health Network Toronto M5G 1L7 Canada.ORCID https://orcid.org/0000-0002-0705-7398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial photodynamic therapy (aPDT) is an alternative to antibiotics that has potential for the treatment of chronic skin wounds, but requires improved, highly selective photosensitizer systems. Rhenium (Re)-complex- and iridium (Ir)-complex-based phospholipid conjugates, as PDT-functional building blocks for liposomes, are presented, and varying structural components and proportion of compounds are explored, including adjusting the cholesterol and polyethylene glycol (PEG)-lipid contents, incorporating ethylenediaminetetraacetic acid (EDTA)-lipid, and introducing the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) to enhance their efficacy and selectivity in aPDT. Ir/Re-liposomes have nanostructurally enhanced photoactivity compared to monomeric Ir/Re-lipids. Ir-liposomes exhibit stronger light absorption and higher emission generation (>threefold) than Re-liposomes, resulting in superior efficacy against

Indexed as

infectionsiridiumliposomesphotodynamic therapyrhenium

Identifiers

PMID40212360
PMCPMC11934977

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.