ArticlePeerJ2025
New role for an old acquaintance: miR-1246 as a new inflammatory and prognostic marker in polytrauma patients.
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Extracellular Vesicle-Derived microRNAs as Fluid Biomarkers in Neurodegenerative Diseases: A Systematic Review.Journal of neurochemistry · 2026Pooled it
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Based on a literature analysis, we hypothesized that miR-1246 has a high potential as new biomarker after trauma. This miRNA is already established in oncology but has not yet been described in polytrauma. Methods: Plasma samples from polytraumatized patients with an ISS ≥ 16 were collected in the emergency room (ER) and 48 hours after trauma. The patients were divided into two groups: a group affected by polytrauma with a leading traumatic brain injury (TBI) (abbreviated injury scale head, AIShead > 4) and a group with a polytrauma without TBI (AIShead = 0). The expression of miR-1246 was measured using qRT-PCR in plasma and plasma extracellular vesicles (EVs). Lastly, we isolated CD171 + EVs by using a magnetic bead-based method and measured miR-1246 expression. Results: In plasma, there was a significant increase in miR-1246 in the ER in polytrauma patients, but not in TBI patients. The EV miRNA expression was also significantly increased in the ER samples of the polytrauma patients (* Conclusion: MiR-1246 was shown to be a marker for the patients' injury severity, the early inflammatory phase and the patients' outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.