ArticleBioactive materials2025
Minimally invasive snakebite inspired microneedle delivery system for internal organs.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Bionic microneedles: Design inspired by bionics and its applications in medicine.International journal of pharmaceutics: X · 2026Review
- A spatiotemporally coordinated curcumin-based microneedle patch for SDF-1α delivery and synergistic myocardial infarction therapy.Journal of nanobiotechnology · 2026Article
- Application of microneedle patches in the alleviation of cardiac infarction in animal models: a systematic review and meta-analysis.Journal of biological engineering · 2026Article
- From conceptual design to translational progress: Emerging advances in intelligent microneedles for biomedical applications.Acta pharmaceutica Sinica. B · 2026Review
- Article
- Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration.Journal of nanobiotechnology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Efficient distribution of therapeutics to the targeted site, particularly internal organs, is essential for their therapeutic success. Here, we developed a therapeutic delivery system targeting internal organs, which features a mechanism akin to a snake's jaw for grasping and deploying detachable microneedles (MNs) embedded with therapeutics. This solves the current challenges of delivering microneedle patches without open chest or abdominal wall surgery. We showed an example of this technology via delivering exosomes derived from mesenchymal stem cells (MSCs) directly to the heart's damaged regions via percutaneous minimally invasive surgery. The shell of MNs is fabricated from methacrylated hyaluronic acid (MeHA), which ensures mechanical strength for myocardium penetration, while the hyaluronic acid (HA) core allows a sustained release of exosomes. In a rat model of myocardial infarction (MI), the delivery of exosomes-loaded microneedles (XOs-MNs) resulted in angiomyogenesis and promoted cardiac function. The feasibility of this microneedle delivery method was also confirmed in a pig model. With its capability to encapsulate a wide range of therapeutic formulations, our system presents a versatile platform for the minimally invasive administration of treatments to internal organs.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.