Evidence map›Paper›PMID 40212780›Full record

ArticleBioactive materials2025

Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration.

Rosalie Bordett, Sama Abdulmalik, Allen Zennifer, Suranji Wijekoon, Sai Sadhananth Srinivasan, Ergin Coskun, Yeshavanth Kumar Banasavadi Siddegowda, Xiaojun Yu, Sangamesh G Kumbar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rosalie BordettDepartment of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-4037, USA.
Sama AbdulmalikDepartment of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Joseph D. & Millie E. Williams Science Hall, 525 S 42nd St, Omaha, NE, 68105, USA.
Allen ZenniferDepartment of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Joseph D. & Millie E. Williams Science Hall, 525 S 42nd St, Omaha, NE, 68105, USA.
Suranji WijekoonDepartment of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Joseph D. & Millie E. Williams Science Hall, 525 S 42nd St, Omaha, NE, 68105, USA.
Sai Sadhananth SrinivasanDepartment of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Joseph D. & Millie E. Williams Science Hall, 525 S 42nd St, Omaha, NE, 68105, USA.
Ergin CoskunDepartment of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-4037, USA.
Yeshavanth Kumar Banasavadi SiddegowdaSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Xiaojun YuDepartment of Biomedical Engineering, Stevens Institute of Technology, 1 Castle Point on Hudson, Hoboken, New Jersey, USA.
Sangamesh G KumbarDepartment of Orthopedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-4037, USA.

Funding

Targeting PHLPP to treat interval disc degeneration using surgical and drug delivery methodsR01AR078908 · NIAMS · EMORY UNIVERSITY · PI Svenja Illien-Junger · 2022 to 2026
$1.9M
Polysaccharide putty formulations for tissue regenerationR01EB034202 · NIBIB · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2023 to 2026
$1.5M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
Supplement to Support the Acquisition of a High-Precision 3D PrinterR01NS134604 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2024 to 2026
$1.3M
Engineered Matrices with Electrical and Chemical Stimulation for Peripheral Nerve RepairR56NS122753 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA · 2022 to 2022
$410k
NIAMS NIH HHS R01 AR078908NIBIB NIH HHS R01 EB030060NIBIB NIH HHS R01 EB034202NINDS NIH HHS R01 NS134604NINDS NIH HHS R56 NS122753
6 · The paper itself

Abstract

Large-gap peripheral nerve injuries (PNI) are often treated with autografts, allografts, or synthetic grafts to facilitate nerve regeneration, but these options are often limited in their availability or functionality. To address these issues, we developed ionically conductive (IC) nerve guidance conduits (NGCs) of sufficient biodegradability, mechanical strength, and bioactivity to support large-gap nerve regeneration. These chitosan-based NGCs release 4-aminopyridine (4-AP) from embedded halloysite nanotubes, and the NGC's IC properties enable transcutaneous electrical stimulation (ES) without invasive electrodes.

Indexed as

4-Aminopyridine (4-AP)Ionically conductive nerve conduitsNeurotrophic factorsPeripheral nerve regenerationSchwann cell proliferationSciatic nerve injury repairTranscutaneous electrical stimulation

Identifiers

PMID40212780
PMCPMC11985093

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.