Evidence map›Paper›PMID 40212783›Full record

ReviewBioactive materials2025

Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration.

Yu Bin Lee, Mi-Lang Kyun, Young Ju Lee, Hye-Eun Shim, Kang Moo Huh, Sun-Woong Kang

Abstract readReview
In one paragraph

Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu Bin LeeCenter for Global Biopharmaceutical Research, Korea Institute of Toxicology, Daejoen, 34114, Republic of Korea.
Mi-Lang KyunCenter for Global Biopharmaceutical Research, Korea Institute of Toxicology, Daejoen, 34114, Republic of Korea.
Young Ju LeeDepartment of Polymer Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea.
Hye-Eun ShimDepartment of Polymer Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea.
Kang Moo HuhDepartment of Polymer Science and Engineering, Chungnam National University, Daejeon, 34134, Republic of Korea.
Sun-Woong KangSchool of Korea Institute of Toxicology, University of Science and Technology, Daejeon, 34114, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclodextrins (CDs), characterized by their unique cyclic oligosaccharide structure and exceptional capacity for molecular encapsulation through host-guest interactions, have garnered significant attention as versatile building blocks in advanced biomaterials. This review explores the application of CD-based biomaterials in tissue engineering and regenerative medicine, emphasizing their synthesis, physicochemical characterization, biocompatibility, and translational potential. Special emphasis is placed on the development of CD-modified hydrogels, their interaction with host-guest molecules, and their use in advanced therapeutic strategies. Additionally, we discuss various fabrication methods for CD-based biomaterials, including physical and covalent crosslinking, self-assembly, and enzymatic crosslinking, each providing unique properties suited for advanced therapeutic strategies. Safety considerations and potential regulatory challenges associated with these materials are also examined. By providing a comprehensive overview of recent advancements, this review aims to highlight the promising role of cyclodextrins as multifunctional tools in enhancing tissue repair and regeneration, paving the way for innovative therapeutic solutions in clinical settings.

Indexed as

BiocompatibilityBiomaterialsCyclodextrinHydrogelRegenerative medicineTissue engineering

Identifiers

PMID40212783
PMCPMC11985092

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.