Evidence map›Paper›PMID 40213417›Full record

ArticleToxicology reports2025

Manganese-induced damage to the serotoninergic system is associated with the development of anxiety and depression.

Valentina Mikhailovna Sviridova, Andrey Pavlovich Ivlev, Elena Anatolievna Kaik, Marina Nikolaevna Karpenko, Irina Sergeevna Ivleva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valentina Mikhailovna SviridovaDepartment of Physiology (Pavlov's), Institute of Experimental Medicine, St. Petersburg 197022, Russia.
Andrey Pavlovich IvlevSechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg 194223, Russia.
Elena Anatolievna KaikNorth-Western State Medical University named after I.I. Mechnikov, St. Petersburg 191015, Russia.
Marina Nikolaevna KarpenkoDepartment of Physiology (Pavlov's), Institute of Experimental Medicine, St. Petersburg 197022, Russia.
Irina Sergeevna IvlevaDepartment of Physiology (Pavlov's), Institute of Experimental Medicine, St. Petersburg 197022, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manganese-induced damage to the serotonergic system was considered to be one of the causes of the development of affective disorders, such as depression and anxiety. However, in the literature, only a few studies could be found on the mechanisms that described the influence of excess manganese levels on the serotonergic system of the central nervous system (CNS). Therefore, it was an important medical and biological task to study the mechanisms underlying the development of affective disorders. This work focused on studying the main mechanisms of the development of affective disorders in male rats under conditions of chronic intranasal administration of manganese chloride (MnCl

Indexed as

Affective disordersAnxietyDepressionManganeseManganismSerotonin

Identifiers

PMID40213417
PMCPMC11982302

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.