Evidence map›Paper›PMID 40213544›Full record

ArticleFrontiers in immunology2025

Characterization of TLR9 responsiveness in cell subsets derived from

Sabina Sánchez Hernández, Tobias Wang Bjerg, Ian Helstrup Nielsen, Anders Laustsen, Hai Q Tang, Lars Henning Pedersen, Eynav Klechevsky, Martin R Jakobsen, Rasmus O Bak

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sabina Sánchez HernándezDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Tobias Wang BjergDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Ian Helstrup NielsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Anders LaustsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Hai Q TangDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Lars Henning PedersenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Eynav KlechevskyDepartment of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, United States.
Martin R JakobsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Rasmus O BakDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.

Funding

The Role of CD5 in Tumor ImmunityR01CA245277 · NCI · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2020 to 2024
$1.8M
Harnessing Human Dendritic Cell Subsets in Skin for the Design of Novel ImmunotherapiesR01AR075959 · NIAMS · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA245277NIAMS NIH HHS R01 AR075959
6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDCs) are multifunctional immune cells with roles in both the innate and adaptive immune system. Their hallmark function is production of large amounts of type I interferons in response to viral infections, but they are also capable of producing a range of other cytokines, antigen presentation, and cytotoxicity. Their potential as an immunotherapy for cancer and infectious disease is being explored, but broad application of these cells is challenged by low frequency in the blood and low viability during

Indexed as

Cell DifferentiationDendritic CellsHematopoietic Stem CellsToll-Like Receptor 9Cells, CulturedHumansInterferon-alphaTranscriptomeInterferon-alphaTLR9 protein, humanToll-Like Receptor 9CD34 hematopoietic stem cellsin vitro differentiationplasmacytoid dendritic cellssubsetstype I IFN

Identifiers

PMID40213544
PMCPMC11983628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.