Evidence map›Paper›PMID 40213670›Full record

ArticleTheranostics2025

Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation.

Wen Zhang, Wenyue Wu, Ning Zhang, Hong Li, Yameng Sun, Xiaodong Ge, Hui Han, Shuyan Chen, Anjian Xu, Sai Santosh Babu Komakula and 8 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Biomedicines · 2026
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wen ZhangLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Wenyue WuLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Ning ZhangLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Hong LiState Key Lab of Digestive Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Yameng SunLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Xiaodong GeDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60612, USA.
Hui HanDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60612, USA.
Shuyan ChenLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Anjian XuState Key Lab of Digestive Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Sai Santosh Babu KomakulaDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60612, USA.
Chao WangDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60612, USA.
Nithyananthan SubramaniyamDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60612, USA.
Qi HanLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Aiting YangState Key Lab of Digestive Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Xuzhen YanState Key Lab of Digestive Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Natalia NietoDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60612, USA.
Hong YouLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Wei ChenState Key Lab of Digestive Health, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfibrillar-associated protein 2 (MFAP-2) is a crucial component of the extracellular matrix (ECM) microfibrils, yet its role in liver fibrosis remains elusive.

Indexed as

Extracellular MatrixExtracellular Matrix ProteinsHepatic Stellate CellsInflammationLiver CirrhosisAnimalsCarbon TetrachlorideDisease Models, AnimalHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutCarbon TetrachlorideExtracellular Matrix Proteinsextracellular matrixhepatic stellate cellLiver fibrosismacrophagematrisome

Identifiers

PMID40213670
PMCPMC11980660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.