Evidence mapPaperPMID 40214605Full record

ReviewNanomaterials (Basel, Switzerland)2025

Potential of Carbon Nanodots (CNDs) in Cancer Treatment.

Walaa Alibrahem, Nihad Kharrat Helu, Csaba Oláh, József Prokisch

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Walaa AlibrahemDoctoral School of Health Sciences, University of Debrecen, Egyetem tér 1, 4028 Debrecen, Hungary.
Nihad Kharrat HeluDoctoral School of Health Sciences, University of Debrecen, Egyetem tér 1, 4028 Debrecen, Hungary.
Csaba OláhMathias Institute, University of Tokaj, Eötvös Str. 7, 3950 Sárospatak, Hungary.ORCID 0000-0001-9598-9322
József ProkischFaculty of Agricultural and Food Sciences and Environmental Management, Institute of Animal Science, Biotechnology and Nature Conservation, University of Debrecen, Böszörményi Street 138, 4032 Debrecen, Hungary.ORCID 0000-0002-1989-0600

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon Nanodots (CNDs) are characterized by their nanoscale size (<10 nm), biocompatibility, stability, fluorescence, and photoluminescence, making them a promising candidate for cancer therapy. The difference in the methods of synthesis of CNDs, whether top-down or bottom-up, affects the formation, visual, and surface characteristics of CNDs, which are crucial for their biomedical and pharmaceutical applications. The urgent need for innovative therapeutic strategies from CNDs is due to the limitations and barriers posed by conventional therapies including drug resistance and cytotoxicity. Nano-loaded chemotherapy treatments are highly effective and can enhance the solubility and targeted delivery of chemotherapeutic agents, generate reactive oxygen species (ROS) to induce cancer cell cytotoxicity, and regulate intracellular signaling pathways. Their ability to be designed for cellular uptake and exact intracellular localization further improves their therapeutic potential. In addition to working on drug delivery, CNDs are highlighted for their dual functionality in imaging and therapy, which allows real-time observing of treatment efficacy. Despite the development of these treatments and the promising results for the future, challenges still exist in cancer treatment.

Indexed as

biocompatibilitycancercarbon nanodotscellular uptakecytotoxicitydrug deliveryfluorescence

Identifiers

PMID40214605
PMCPMC11990490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.