SynthesisArchives of orthopaedic and trauma surgery2025
Continuous femoral nerve block as pain management following total knee arthroplasty: a systematic review.
Synthesis in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Perioperative comparison between robotic-assisted and freehand total knee arthroplasty : A quasi-randomized controlled trial.Orthopadie (Heidelberg, Germany) · 2026Trial
- Does robotic assistance influence the length of stay after total knee arthroplasty?Journal of robotic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe present systematic review evaluated the current level of I evidence on continuous femoral nerve block (FNB) as pain management following total knee arthroplasty (TKA), comparing different drugs. MATERIALS AND
methodsThis study followed the 2020 PRISMA guidelines. PubMed, Embase and Web of Science were accessed in November 2024. All clinical studies concerning continuous FNB for pain management following TKA were considered.
resultsData from 22 RCTs were retrieved. The drugs included in the analyses were levobupivacaine, bupivacaine and ropivacaine in isolation or combined with prilocaine or dexmedetomidine. A statistically significant difference was found in VAS at rest in postoperative day (POD) 0 (p < 0.01): the bupivacaine group demonstrated the highest values, and the ropivacaine combined with dexmedetomidine group had the lowest values. No other statistically significant difference in VAS at rest was found for any group in POD 1, 2, and 3 (p = 0.1, p = 0.1, and p = 0.4, respectively). The groups receiving ropivacaine combined with dexmedetomidine and prilocaine had the lowest values of VAS during activity in POD2 (p < 0.01), while in POD3 the groups receiving ropivacaine combined with prilocaine and the bupivacaine one had the lowest values (p < 0.01). No significant difference was found in VAS during activity between any group in POD 0 (p = 0.4) and POD 1 (p = 0.3).
conclusionRopivacaine combined with dexmedetomidine might be the best compound for continuous femoral nerve block to manage pain following TKA during the first PODs. Further high-quality investigations are necessary to validate these findings in clinical settings.
Indexed as
Identifiers
40214694What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.