Evidence map›Paper›PMID 40215323›Full record

ArticleScience immunology2025

Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts.

Hung Chan, Fengwu Li, Tatsuya Dokoshi, Kellen J Cavagnero, Qing Li, Yang Chen, Carlos Aguilera, Teruaki Nakatsuji, Edward Liu, Aaryan Indra and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Fibroblasts resistScience advances · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hung ChanDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0009-0156-4952
Fengwu LiDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5092-770X
Tatsuya DokoshiDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3678-6781
Kellen J CavagneroDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4160-6394
Qing LiDermatology Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-0169-8098
Yang ChenDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0164-8971
Carlos AguileraDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.
Teruaki NakatsujiDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.
Edward LiuDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.
Aaryan IndraDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5609-577X
Daping YangInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031,China.ORCID 0000-0002-3104-1943
Ottaviani ValentinaMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0006-5528-2887
Tomofumi NumataDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0004-2285-1030
Brittany CrownDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0001-0206-1507
Henry LiDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0007-5974-779X
Kevin J WilliamsDepartment of Biological Chemistry and UCLA Lipidomics Lab, UCLA, Los Angeles, CA, USA.ORCID 0000-0001-8091-7924
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0723-4841
Steven J BensingerDepartment of Microbiology, Immunology, and Molecular Genetics, UCLA Lipidomics Lab and Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.ORCID 0000-0002-9657-4206
WanJun ChenMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-1401-7861

Funding

Microbiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2M
Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
Staphylococcus aureus induced itch and neuro-immune signaling in skin infectionsR01AI168005 · NIAID · HARVARD MEDICAL SCHOOL · PI Isaac Ming-Cheng Chiu, ALEXANDER R HORSWILL · 2022 to 2026
$3.7M
Microbiome Function in Atopic DermatitisU01AI152038 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo · 2020 to 2026
$3.3M
Inflammatory cross-talk between skin and gutR01DK128787 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, SALZMAN, NITA H · 2021 to 2024
$2.6M
NIAID NIH HHS R01 AI168005NIAID NIH HHS R37 AI052453NIAID NIH HHS U01 AI152038NIAMS NIH HHS P50 AR080594NIDDK NIH HHS R01 DK128787
6 · The paper itself

Abstract

Infections after psychological stress are a major health care problem. Single-cell transcriptomics and lipidomic profiling in a mouse model of stress show that dermal fibroblasts undergoing adipogenesis have defective responses to

Indexed as

FibroblastsStaphylococcal Skin InfectionsStress, PsychologicalTransforming Growth Factor betaAnimalsCathelicidinsMaleMiceMice, Inbred C57BLMice, KnockoutSkinStaphylococcus aureusCathelicidinsTransforming Growth Factor beta

Identifiers

PMID40215323
PMCPMC12183641

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.