Evidence map›Paper›PMID 40216052›Full record

ArticleBiological psychiatry2026

Designing Clinical Trials for an Inflammatory Subtype of Major Depressive Disorder.

Andrew H Miller, Jennifer C Felger, Ebrahim Haroon

Abstract read
In one paragraph

Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. CD4Frontiers in psychiatry · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew H MillerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia. Electronic address: amill02@emory.edu.
Jennifer C FelgerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Ebrahim HaroonDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.

Funding

The Role of Inflammation in CNS Mechanisms of Anhedonia and Psychomotor Slowing in Depressed PWH as Determined using a Next Generation TNF AntagonistR01MH128872 · NIMH · EMORY UNIVERSITY · PI Jennifer C Felger, ANDREW H MILLER · 2021 to 2026
$3.1M
Leucine as a Probe of Kynurenine-Induced Glutamate and Neural Circuit Dysfunction in Midlife DepressionR01MH132059 · NIMH · EMORY UNIVERSITY · PI Ebrahim Haroon · 2023 to 2026
$2.8M
Inflammation-Induced CNS Glutamate as a Function of Depression in Middle AgeR01MH107033 · NIMH · EMORY UNIVERSITY · PI HAROON, EBRAHIM · 2016 to 2021
$2.2M
Phenotyping Major Depression with Increased InflammationR01MH087604 · NIMH · EMORY UNIVERSITY · PI MILLER, ANDREW H · 2010 to 2014
$2.2M
Dopaminergic Therapy for Inflammation-Related Anhedonia in DepressionR33MH121625 · NIMH · EMORY UNIVERSITY · PI FELGER, JENNIFER C · 2023 to 2025
$2.1M
Inflammation-Induced CNS Glutamate Changes in DepressionR01MH112076 · NIMH · EMORY UNIVERSITY · PI HAROON, EBRAHIM, MILLER, ANDREW H · 2016 to 2020
$2.0M
JAK Signaling as a Mechanism of Inflammation-related Reward and Motor Circuit Deficits in DepressionR01MH140180 · NIMH · EMORY UNIVERSITY · PI Jennifer C Felger, Christina Gavegnano · 2025 to 2026
$1.3M
NIMH NIH HHS R01 MH087604NIMH NIH HHS R01 MH107033NIMH NIH HHS R01 MH112076NIMH NIH HHS R01 MH128872NIMH NIH HHS R01 MH132059NIMH NIH HHS R01 MH140180NIMH NIH HHS R33 MH121625
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40216052
PMCPMC13425400

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.