Evidence map›Paper›PMID 40216712›Full record

ArticleDoklady. Biochemistry and biophysics2025

The bxd PRE from Bithorax Complex of Drosophila melanogaster Has Weak Insulator Activity.

A N Ibragimov, O V Kyrchanova, Y E Vorontsova, E N Kozlov, V O Dubrovskaya, P G Georgiev

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A N IbragimovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. airat.ibra@gmail.com.
O V KyrchanovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Y E VorontsovaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
E N KozlovInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
V O DubrovskayaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
P G GeorgievInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autonomous functioning of regulatory domains in the Bithorax complex (BX-C) of Drosophila melanogaster is maintained by boundaries (insulators) that prevent inappropriate enhancer-promoter interactions. Polycomb response elements (PREs) maintain epigenetic memory within regulatory domains and are often located near insulators, enhancing their blocking activity. The bxd PRE is a well-characterized silencer that regulates the bxd/pbx domain of the Ubx gene in the first abdominal segment. We used a boundary replacement strategy to assess the insulator activity of the bxd PRE. Substituting the bxd PRE for the Fab-7 boundary, which separates the Abd-B regulatory domains in the BX-C, revealed that the bxd PRE has weak insulator activity.

Indexed as

Drosophila melanogasterDrosophila ProteinsHomeodomain ProteinsInsulator ElementsResponse ElementsTranscription FactorsAnimalsPolycomb-Group ProteinsDrosophila ProteinsHomeodomain ProteinsPolycomb-Group ProteinsTranscription FactorsUbx protein, Drosophilabxd/pbx domainchromatin insulatorsGAFPhopolycombPRE

Identifiers

PMID40216712

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.