Evidence map›Paper›PMID 40216925›Full record

ArticleScientific reports2025

Oxylipins as canine sepsis indicators in vivo and in ex vivo skin organ culture model.

Denise Biagini, Chiara Di Franco, Giulia Lazzarini, Vincenzo Miragliotta, Tommaso Lomonaco, Fabio Di Francesco, Angela Briganti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denise Biagini *Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
Chiara Di Franco *Department of Veterinary Sciences, University of Pisa, Pisa, Italy.
Giulia LazzariniDepartment of Veterinary Sciences, University of Pisa, Pisa, Italy.
Vincenzo MiragliottaDepartment of Veterinary Sciences, University of Pisa, Pisa, Italy. vincenzo.miragliotta@unipi.it.
Tommaso LomonacoDepartment of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
Fabio Di Francesco *Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy.
Angela Briganti *Department of Veterinary Sciences, University of Pisa, Pisa, Italy.

Funding

Università di Pisa PRA_2020_33
6 · The paper itself

Abstract

Sepsis, a life-threatening condition characterized by a dysregulated immune response to infection, remains a significant cause of mortality in both humans and veterinary patients. This study explores oxylipins as potential indicators of sepsis in dogs through in vivo plasma analysis and an ex vivo lipopolysaccharide (LPS)-treated skin organ culture model. By employing a robust analytical platform, 52 oxylipins and 4 polyunsaturated fatty acids were profiled in plasma and skin cultures. Results revealed distinct biochemical and morphological changes, with LPS triggering capillary vasodilation and time-dependent increases in pro-inflammatory mediators such as PGE

Indexed as

OxylipinsSepsisSkinAnimalsBiomarkersDinoprostoneDogsLipopolysaccharidesOrgan Culture TechniquesBiomarkersDinoprostoneLipopolysaccharidesOxylipins

Identifiers

PMID40216925
PMCPMC11992227

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.