Evidence map›Paper›PMID 40216962›Full record

ArticleScientific reports2025

MicroRNA profiling reveals novel biomarkers for cardiovascular and psychological health in plateau psycho CVD.

Xiu-Long Niu, Guo-Qing Liang, Shao-Bo Chen, Yan Li, Tao Wang, Xiaojing Wang, Qing Guo, Dong Gu, Le Kang, Changxing Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiu-Long Niu *Department of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.ORCID http://orcid.org/0000-0003-4779-9318
Guo-Qing Liang *Department of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Shao-Bo Chen *Department of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Yan LiDepartment of Family Planning, The Second Hospital of Tianjin Medical University, Tianjin, China.
Tao WangDepartment of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Xiaojing WangDepartment of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Qing GuoDepartment of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Dong GuDepartment of Cardiology, General Hospital of PAP, Lhasa Tibet, 850000, China.
Le KangDepartment of Health Care Center, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Changxing LiuDepartment of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China.
Xun BiDepartment of Medical Examination and Identification, Characteristic Medical Center of PAP, Tianjin, 300162, China. tijianbixun@163.com.
Wei CaiDepartment of Prevention and Therapy of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of PAP, Tianjin, 300162, China. cardiolabcaiwei@163.com.

Funding

the Independent innovation research projects of Characteristic Medical Center of PAP KYZZCX2401the Independent innovation research projects of Characteristic Medical Center of PAP KYZZCX2425
6 · The paper itself

Abstract

This study aimed to explore the expression characteristics of miRNAs in cardiovascular diseases (CVD) and depression within a plateau environment, to better understand their potential role in Plateau Psycho-CVD. A prospective study design was employed to analyze circulating small RNAs from 20 subjects using high-throughput sequencing technology. Participants were divided into four groups (C, PPC, PP, PC) for comparative analysis. Differentially expressed miRNAs were selected for further functional enrichment analysis. The findings revealed that hsa-miR-1976 and hsa-miR-4685-3p were significantly upregulated in patients with Plateau Psycho-CVD and mental health issues. These miRNAs were closely associated with key pathways relevant to cardiovascular and mental health, including the PI3K-Akt and neurotrophin signaling pathways. Additionally, the downregulated miRNAs in the PPC group were linked to increased expression of AKT1 and STAT3, genes associated with bipolar disorder and inflammatory pathways, indicating a potential impact on neural function. This study identifies hsa-miR-1976 and hsa-miR-4685-3p as novel biomarkers for plateau stress dual heart disease, with AKT1 and STAT3 emerging as potential therapeutic targets. These insights pave the way for further research and clinical applications in related fields.

Indexed as

Cardiovascular DiseasesDepressionMicroRNAsAdultBiomarkersFemaleGene Expression ProfilingHumansMaleMental HealthMiddle AgedProspective StudiesProto-Oncogene Proteins c-aktSignal TransductionSTAT3 Transcription FactorAKT1 protein, humanBiomarkersMicroRNAsProto-Oncogene Proteins c-aktSTAT3 protein, humanSTAT3 Transcription Factorhsa-miR-1976hsa-miR-4685-3pKT1PlateauPsycho-CVDSTAT3

Identifiers

PMID40216962
PMCPMC11992083

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.