Evidence map›Paper›PMID 40217656›Full record

ReviewJournal of clinical medicine2025

The Link Between Sleep-Related Breathing Disorders and Idiopathic Pulmonary Fibrosis: Pathophysiological Mechanisms and Treatment Options-A Review.

Athina Patsoura, Giulia Baldini, Daniele Puggioni, Matteo Delle Vergini, Ivana Castaniere, Dario Andrisani, Filippo Gozzi, Anna Valeria Samarelli, Giulia Raineri, Sofia Michelacci and 8 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Athina PatsouraRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Giulia BaldiniRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Daniele PuggioniRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Matteo Delle VerginiRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Ivana CastaniereRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Dario AndrisaniRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0003-3860-0063
Filippo GozziRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Anna Valeria SamarelliExperimental Pneumology Laboratory, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Giulia RaineriExperimental Pneumology Laboratory, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Sofia MichelacciRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Cristina RuiniRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Andrea CarzoliRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Aurelia CuculoRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Alessandro MarchioniRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0003-3720-3517
Bianca BeghèRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.
Enrico CliniRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0002-1515-5094
Stefania CerriRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0003-4612-1580
Roberto TonelliRespiratory Disease Unit, Department of Medical and Surgical Sciences of Motherhood and Child, University Hospital of Modena, 41125 Modena, Italy.

Funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The realization of this project produced as part of the research program at Experimental Pneumology, University of Modena and Reggio Emi See manuscript
6 · The paper itself

Abstract

In recent years, several studies have examined the impact of sleep-disordered breathing (SBD) on the quality of life and prognosis of patients with idiopathic pulmonary fibrosis (IPF). Among these disorders, obstructive sleep apnea (OSA) and nocturnal hypoxemia (NH) are the most prevalent and extensively studied, whereas central sleep apnea (CSA) has only been documented in recent research. The mechanisms underlying the relationship between IPF and SBDs are complex and remain an area of active investigation. Despite growing recognition of SBDs in IPF, no standardized guidelines exist for their management and treatment, particularly in a population characterized by distinct structural pulmonary abnormalities. This review outlines the pathophysiological connections between sleep-breathing disorders (SBDs) and idiopathic pulmonary fibrosis (IPF), as well as current therapeutic options. A comprehensive literature search using PubMed identified relevant studies, confirming the efficacy of CPAP in treating severe OSA and CSA. While high-flow oxygen therapy has not been validated in this patient cohort, it may offer a potential solution for select patients, particularly the elderly and those with low compliance. Conventional oxygen therapy, however, is limited to cases of isolated nocturnal hypoxemia or mild central sleep apnea.

Indexed as

central sleep apneacontinuous positive airway pressureconventional oxygen therapyhigh-flow nasal cannulaidiopathic pulmonary fibrosisnocturnal hypoxemiaobstructive sleep apneasleep breathing disorders

Identifiers

PMID40217656
PMCPMC11989984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.