Evidence mapPaperPMID 40217836Full record

ReviewJournal of clinical medicine2025

A Narrative Review of Independent Treatment Methods for ED: Assessment of the Effectiveness of Diet, Supplements, Pharmacotherapy, and Physiotherapy.

Marta Bonarska, Damian Adasik, Simone Szymczyk, Gabriela Łocik, Elżbieta Bumbul-Mazurek, Piotr Marianowski, Artur Ludwin

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marta Bonarska1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.ORCID 0009-0008-7201-2082
Damian Adasik1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.ORCID 0009-0000-5800-8919
Simone Szymczyk1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.ORCID 0009-0002-7831-3667
Gabriela Łocik1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.
Elżbieta Bumbul-Mazurek1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.
Piotr Marianowski1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.
Artur Ludwin1st Department of Obstretrics and Gynaecology, University Centre for Women and Newborn Health, pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.ORCID 0000-0001-5853-8661

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of erectile dysfunction (ED) among the male population worldwide has significant ramifications for their quality of life and psychological well-being. This narrative review explores both conventional treatments, such as pharmacotherapy and surgery, and emerging approaches, including regenerative therapies, dietary interventions, physiotherapy, and vacuum erection devices (VEDs). Unlike prior reviews, this study emphasises unconventional therapies and their role in comprehensive ED management. A systematic literature review was conducted using PubMed, Embase, and Medline, including studies published up to 2024. Keywords such as "ED", "pharmacotherapy", "shock wave therapy", "regenerative medicine", and "dietary interventions" were used to identify relevant studies. Eligible studies examined treatment efficacy, mechanisms, and patient outcomes. Phosphodiesterase type 5 (PDE5i) inhibitors remain the primary treatment, demonstrating effectiveness across diverse populations. Regenerative therapies, including stem cells and platelet-rich plasma (PRP), show promise, but require further validation. Surgical interventions, particularly penile prostheses, provide high patient and partner satisfaction. Non-invasive methods, including physiotherapy and dietary changes like adoption of the Mediterranean diet, improve vascular health and erectile function. The efficacy of VEDs as standalone or adjunct treatments has been demonstrated, enhancing outcomes in prosthetic surgery. A multimodal, personalised approach is essential for optimising ED treatment. Despite promising advancements, gaps remain in terms of long-term data, standardised protocols, and partner-centred outcomes. Future research should focus on large-scale, multi-centre trials and synergistic treatment approaches to improve therapeutic outcomes and patient satisfaction.

Indexed as

dietepimediumerectile dysfunctionginsengmanual therapiesMediterranean dietpelvic floor muscle exercisespenile prosthesesregenerative medicineshock wave therapyyohimbine

Identifiers

PMID40217836
PMCPMC11989648

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.