Evidence mapPaperPMID 40219004Full record

SynthesisNutrients2025

Impact of Gut Microbiome Modulation on Uremic Toxin Reduction in Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis.

Renata Cedillo-Flores, Miguel Angel Cuevas-Budhart, Iván Cavero-Redondo, Maria Kappes, Marcela Ávila-Díaz, Ramón Paniagua

Registry-linked trialAbstract readSystematic ReviewNetwork Meta-Analysis
In one paragraph

Synthesis in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07483697 (Multimodal Intervention and Its Association With Reduced Dysbiosis and Inflammation in Early Chronic Kidney Disease in Young People), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07483697 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Multimodal Intervention and Its Association With Reduced Dysbiosis and Inflammation in Early Chronic Kidney Disease in Young People: a Prospective Study

TypeinterventionalSponsorCentenario Hospital Miguel HidalgoRan2026 to 2026Enrolled200ConditionsExercise, Diet Interventions, Symbiotic, CKD Stage 1Armssymbiotic, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Gut-kidney axis: Dysbiosis and renal disease.World journal of nephrology · 2026
    Review
  13. Review
  14. Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.International journal of molecular sciences · 2026
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Renata Cedillo-FloresUnidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, Mexico.
Miguel Angel Cuevas-BudhartUnidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, Mexico.ORCID 0000-0002-3379-0147
Iván Cavero-RedondoCarVasCare Research Group, Facultad de Enfermería de Cuenca, Universidad de Castilla la Mancha, 16002 Cuenca, Spain.ORCID 0000-0003-2617-0430
Maria KappesFaculty of Healthcare Sciencies, Nursing School, Universidad San Sebastián, Puerto Montt 5501842, Chile.ORCID 0000-0001-8101-3898
Marcela Ávila-DíazUnidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, Mexico.ORCID 0000-0001-8855-9682
Ramón PaniaguaUnidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, Mexico.ORCID 0000-0003-3577-9707

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gastrointestinal MicrobiomeRenal Insufficiency, ChronicUremic ToxinsCresolsDysbiosisFemaleHumansMalePrebioticsProbioticsRandomized Controlled Trials as TopicSynbioticsCresolsPrebioticsUremic Toxinschronic kidney diseasegut microbiotaprebioticsprobioticssynbioticsuremic toxins

Identifiers

PMID40219004
PMCPMC11990722

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.