Evidence map›Paper›PMID 40219348›Full record

ReviewPolymers2025

Engineering Adhesive Hydrogels for Hemostasis and Vascular Repair.

Juya Jeon, Shri Venkatesh Subramani, Kok Zhi Lee, Santiago Elizondo-Benedetto, Mohamed Adel Zayed, Fuzhong Zhang

Abstract readReview
In one paragraph

Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. EnhancingApplied and environmental microbiology · 2025
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juya JeonDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.ORCID 0000-0001-7723-9413
Shri Venkatesh SubramaniDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Kok Zhi LeeDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.ORCID 0000-0002-1836-2662
Santiago Elizondo-BenedettoSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, Saint Louis, MO 63130, USA.ORCID 0000-0002-0911-8086
Mohamed Adel ZayedSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine in St. Louis, Saint Louis, MO 63130, USA.
Fuzhong ZhangDepartment of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.ORCID 0000-0001-6979-7909

Funding

Targeted delivery of a proangiogenic and promyogenic protein for regeneration of diabetic ischemic limbsR01HL164062 · NHLBI · WASHINGTON UNIVERSITY · PI GUAN, JIANJUN, ZHANG, FUZHONG · 2022 to 2025
$2.3M
DMR 2105150DMR 2207879NIH HHS R01HL164062
6 · The paper itself

Abstract

Adhesive hydrogels with tunable mechanical properties and strong adhesion to wet, dynamic tissues have emerged as promising materials for tissue repair, with potential applications in wound closure, hemorrhage control, and surgical adhesives. This review highlights the key design principles, material classifications, and recent advances in adhesive hydrogels designed for vascular repair. The limitations of existing adhesive hydrogels, including insufficient mechanical durability, suboptimal biocompatibility, and challenges in targeted delivery, are critically evaluated. Furthermore, innovative strategies-such as incorporating self-healing capabilities, developing stimuli-responsive systems, integrating functional nanocomposites, and employing advanced fabrication techniques like 3D bioprinting-are discussed to enhance adhesion, mechanical stability, and vascular tissue regeneration. While significant progress has been made, further research and optimization are necessary to advance these materials toward clinical translation, offering a versatile and minimally invasive alternative to traditional vascular repair techniques.

Indexed as

adhesive hydrogelhemostasisprotein polymerssurgical adhesivesvascular repair

Identifiers

PMID40219348
PMCPMC11991510

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.