Evidence map›Paper›PMID 40219551›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2025

[Expression and regulatory mechanism of miR-34a in neonatal rat model of bron-chopulmonary dysplasia induced by hyperoxia].

Mengyue Huo, Hua Mei, Yuheng Zhang, Yanbo Zhang, Chunli Liu

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mengyue HuoDepartment of Neonatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Hua MeiDepartment of Neonatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Yuheng ZhangDepartment of Neonatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Yanbo ZhangDepartment of Neonatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Chunli LiuDepartment of Neonatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the expression and possible regulatory mechanism of miR-34a in the lung tissue of neonatal rat model of bronchopulmonary dysplasia (BPD) induced by hyperoxia.

methodsIn the study, 80 newborn SD rats were randomly divided into hyperoxia group (FiO

resultsThe weight of rats in the hyperoxia group on the 7th, 14th and 21st days after birth was significantly lower than that in the air group (

conclusionThe new BPD model of newborn SD rats can be successfully established by continuous exposure to 60% hyperoxia. The expression of miR-34a was up-regulated in the lung tissue of the new BPD model of neonatal rats. MiR-34a may play an important role in the occurrence and development of BPD by regulating Ang-1/Tie-2 signal pathway.

Indexed as

Bronchopulmonary DysplasiaHyperoxiaMicroRNAsAngiopoietin-1AnimalsAnimals, NewbornDisease Models, AnimalLungMaleRatsRats, Sprague-DawleyReceptor, TIE-2Angiopoietin-1Angpt1 protein, ratMicroRNAsMIRN34 microRNA, ratReceptor, TIE-2Angiopoietin-1 (Ang-1)Bronchopulmonary dysplasia (BPD)HyperoxiamiR-34aTyrosine kinase receptor-2 (Tie-2)

Identifiers

PMID40219551
PMCPMC11992441

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.