ArticleJournal of diabetes science and technology2025
Time at High Risk of Hypoglycemia: Validation of a Consensus-Based Continuous Glucose Monitoring-Metric for Hospitalized Patients.
Article in Journal of diabetes science and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Implementation of a Multihospital Electronic Medical Record-Based Insulin Order Set to Reduce Hypoglycemic Events.AACE endocrinology and diabetesArticle
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTime at high risk of hypoglycemia (THRH), 3.9 to 5.6 mmol/L, is a continuous glucose monitoring (CGM)-based metric recommended for reporting in hospitalized patients. This study aims to validate THRH as a predictor of hypoglycemia.
methodsThe CGM data from 166 non-intensive care unit (non-ICU) inpatients with type 2 diabetes from the DIATEC trial were analyzed. All participants received basal-bolus insulin therapy. Of these, 82 were monitored with point-of-care glucose testing and blinded CGM, while 84 had open CGM. Linear and negative binomial regression analyses assessed the relationship between THRH and time below range (TBR) (<3.0 mmol/L, 3.0-3.9 mmol/L, and <3.9 mmol/L) and hypoglycemic events. Analyses were conducted for day (07:00-23:00), night (23:01-06:59), and 24-hour periods.
resultsFor CGM-monitored patients, every 10%-point increase in THRH was associated with a 0.13%-point increase in TBR (<3.0 mmol/L) (95% confidence interval [CI] = 0.06-0.21), 0.66%-point increase in TBR (3.0-3.9 mmol/L) (95% CI = 0.47-0.86), and 0.74%-point increase in TBR (<3.9 mmol/L) (95% CI = 0.51-0.97), all
conclusionsThe THRH is strongly associated with hypoglycemia in non-ICU hospitalized patients with type 2 diabetes on basal-bolus insulin. Aiming for THRH below 50% aligns with the recommended TBR target of <3.9 mmol/L below 4%, supporting THRH's role in guiding hypoglycemia prevention strategies.
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