Evidence map›Paper›PMID 40220120›Full record

ArticleInternational urology and nephrology2025

Identification of risk factors for renal progression in adults with IgAV: a retrospective cohort study of a single center in northwest China.

Yingying Wang, Xiaochun Zhou, Gang Cheng, Rongrong Zhu, Zizhao Qi, Wenjun Zhang, Hong Shu, Wei Liu, Gouqin Wang, Qian Pu and 2 more

Abstract read
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In one paragraph

Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yingying Wang *The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Xiaochun Zhou *The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Gang ChengThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Rongrong ZhuThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Zizhao QiThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Wenjun ZhangThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Hong ShuThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Wei LiuThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Gouqin WangThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Qian PuThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Yuke KongThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Jianqin WangThe Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. ery_wangjqery@lzu.edu.cn.

Funding

Cuiying Scientific and Technological Innovation Programof' The Second Hospital & Clinical Medical School, Lanzhou University CY2024-QN-B09Gansu Province Traditional Chinese Medicine research project GZKG-2024-73Lanzhou science and technology planning project 2023-4-19Natural Science Foundation of Gansu Province 22JR11RA067The International Cooperation Project of Gansu Provincial Science and Technology Department 24YFWA012
6 · The paper itself

Abstract

objectivesThis investigation sought to examine the clinical and pathological characteristics, outcomes, and risk factors linked to the progression of renal function in adult-onset immunoglobulin A (IgA) vasculitis within a single center in northwest China.

methodsData were retrospectively gathered from cases of adult-onset IgA vasculitis recorded at a tertiary hospital in northwest China, covering the period from January 2013 to August 2024. During the follow-up, clinical information was compared between patients who advanced to chronic kidney disease (CKD) stage 3 and those who did not.

resultsA sum of 1082 adult-onset IgA vasculitis patients (632 men; median age of 37 years) were included. Among patients with baseline proteinuria >0.5 g/24h (43.9%), 40.7% progressed to chronic kidney disease (CKD) stage 3, while 5.1% developed end-stage renal disease (ESRD). COX regression analysis indicated that older age, renal pathological grade IV, hypertension (HTN), diabetes, hyperlipidemia, and hyperuricemia were independent risk factors for CKD stage 3 progression in individuals with adult-onset IgA vasculitis.

conclusionsOlder age and comorbidities such as hypertension and diabetes significantly increase the risk of renal progression in adult-onset IgAV. Early management of these comorbidities may mitigate the risk of CKD progression.

Indexed as

IgA VasculitisImmunoglobulin ARenal Insufficiency, ChronicAdultChinaCohort StudiesDisease ProgressionFemaleGlomerulonephritis, IGAHumansMaleMiddle AgedRetrospective StudiesRisk FactorsImmunoglobulin AAdult onset IgA vasculitisChronic kidney diseaseHenoch schönlein purpuraRisk factor

Identifiers

PMID40220120

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.