Evidence map›Paper›PMID 40220127›Full record

ArticleMetabolic brain disease2025

Gut microbiota and blood metabolites: unveiling their roles in hippocampal volume changes through Mendelian randomization and mediation analysis.

Zijin Huang, Xueke Du, Fangzhou Li, Zhixuan Lan, Liang Guo, Linghui Pan

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zijin HuangDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530021, People's Republic of China.
Xueke DuDepartment of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning, 530007, People's Republic of China.
Fangzhou LiDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530021, People's Republic of China.
Zhixuan LanDepartment of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning, 530007, People's Republic of China.
Liang GuoDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530021, People's Republic of China.
Linghui PanDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530021, People's Republic of China. panlinghui@gxmu.edu.cn.

Funding

General Project of Guangxi Natural Science Foundation (Joint Special Project for Regional High incidence Disease Research) 2022JJA140239Guangxi Zhuang Autonomous Region Health and Family Planning Commission Self-raised Funds Z20170078Guangxi Zhuang Autonomous Region Traditional Chinese Medicine Administration Self-raised Funds GXZYZ20210513Guangxi Zhuang Autonomous Region Western medicine Medicine Administration Self-raised Funds Z-A20230600
6 · The paper itself

Abstract

Changes in hippocampal volume (HV) are linked to various neuropsychiatric disorders. Observational studies suggest associations of gut microbiota (GM) and blood metabolites (BM) with changes in HV; however, their causal relationships remain unclear. We aimed to use Mendelian randomization (MR) to investigate the causal associations of GM and BM with changes in HV and to explore the potential mediating role of BM. Using two-sample MR (TSMR) analysis, we examined 412 GM traits and 1,400 BM traits with a focus on their causal relationships with age-independent/dependent longitudinal changes in HV, primarily using the inverse variance weighted method. Furthermore, we explored the mediating role of BM through a two-step MR design. We identified 44 GM traits and 175 BM traits having nominally significant causal associations with age-independent/dependent longitudinal changes in HV. In addition, the glycine-to-pyridoxal ratio (mediation proportion: 7.38%) and the phosphate-to-citrate ratio (mediation proportion: 12.55%) mediated the effect of the pathway of L-arginine degradation II on the reduction of age-independent longitudinal changes in HV. Our study reveals the causal effects of GM and BM on longitudinal changes in HV and identifies BM traits with mediating roles. These findings offer valuable insights for the prevention and treatment of the related neuropsychiatric disorders.

Indexed as

Gastrointestinal MicrobiomeHippocampusAdultFemaleHumansMagnetic Resonance ImagingMaleMediation AnalysisMendelian Randomization AnalysisMiddle AgedOrgan SizeBlood metabolitesGut microbiotaHippocampal volumeLongitudinal changesMendelian randomization

Identifiers

PMID40220127

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.