Evidence map›Paper›PMID 40220135›Full record

ArticleClinical & experimental metastasis2025

A new, immunocompetent brain-metastatic mouse model of HER2-positive breast cancer.

Leran Chen, Angela Chow, Wanchao Ma, Courtney Coker, Yifan Gu, Peter Canoll, Manoj Kandpal, Hanina Hibshoosh, Anup K Biswas, Swarnali Acharyya

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical & experimental metastasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leran ChenInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA.
Angela ChowInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA.
Wanchao MaInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA.
Courtney CokerInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA.
Yifan GuInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA.
Peter CanollDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, 630 W 168th St, New York, NY, 10032, USA.
Manoj KandpalCenter for Clinical and Translational Science, Rockefeller University Hospital, 1230 York Ave, New York, NY, 10065, USA.
Hanina HibshooshDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, 630 W 168th St, New York, NY, 10032, USA.
Anup K BiswasInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA.
Swarnali AcharyyaInstitute for Cancer Genetics, Columbia University Irving Medical Center, 1130 St Nicholas Avenue, New York, NY, 10032, USA. sa3141@cumc.columbia.edu.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
NCATS NIH HHS UL1 TR001866NCI NIH HHS P30 CA013696
6 · The paper itself

Abstract

Brain metastasis is a common and devastating complication of cancer that affects over 50% of HER2-positive (HER2

Indexed as

Brain NeoplasmsBreast NeoplasmsDisease Models, AnimalErb-b2 Receptor Tyrosine KinasesAnimalsCell Line, TumorFemaleHumansImmunocompetenceMiceErb-b2 Receptor Tyrosine KinasesBrain metastasisHER2-positive breast cancer

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.