Evidence map›Paper›PMID 40220148›Full record

ArticleCellular and molecular life sciences : CMLS2025

m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.

Yan Hu, Lulu Yang, Liting Huang, Chao Zeng, Siying Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Stem cell therapy targets THBS1 to reverse endometrial fibrosis.Frontiers in cell and developmental biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan HuDepartment of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Lulu YangDepartment of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Liting HuangDepartment of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Chao ZengDepartment of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
Siying RenDepartment of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China. syren@csu.edu.cn.ORCID http://orcid.org/0000-0001-6618-690X

Funding

Changsha Municipal Natural Science Foundation kq2208333Health Commission of Hunan Province W20243218Natural Science Foundation of Hunan Province 2023JJ40825
6 · The paper itself

Abstract

N6-methyladenosine (m6A) modification, a dynamically reversible epigenetic mechanism, is implicated in pulmonary fibrosis (PF) progression. The function and molecular mechanisms of m6A reader, insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) in PF remain elusive. This study investigates the mechanistic contributions of IGF2BP1 to PF development. We found IGF2BP1 was overexpressed in macrophages of PF mice. IGF2BP1 knockdown markedly attenuated bleomycin (BLM)-induced lung pathology, as evidenced by reduced inflammatory cell infiltration, fibroblast accumulation, Ashcroft fibrosis scores, and hydroxyproline deposition. Furthermore, IGF2BP1 knockdown downregulated PF-associated markers in lung tissues and embryonic lung fibroblasts (ELFs), including TGF-β1, α-SMA, Collagen-I/III, Arg1, CCL18, Ym1, CD163, IL-6, IL-1β, and TIMP1, while decreasing the CD68

Indexed as

AdenosineGlycolysisMacrophagesPulmonary FibrosisRNA-Binding ProteinsRNA, MessengerThrombospondin 1AnimalsBleomycinFibroblastsHumansLungMaleMiceMice, Inbred C57BLPhenotypeAdenosineBleomycinN-methyladenosineRNA-Binding ProteinsRNA, MessengerThbs1 protein, mouseThrombospondin 1Toll-Like Receptor 4Glycolytic metabolismInsulin-like growth factor 2 mRNA binding protein 1Macrophage polarizationn6-methyladenosinePulmonary fibrosisThrombospondin-1

Identifiers

PMID40220148
PMCPMC11993514

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.