Evidence map›Paper›PMID 40220186›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

circ_0006168 expression serves as a potential biomarker of acquired middle ear cholesteatoma.

Chen Liu, Bo Ning, Bing Liu, Liangjun Cheng, Huachao Li, Mei Ma

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chen LiuDepartment of Otolaryngology-Hand and Neck Surgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, No.199, Jiefang South Road, Xuzhou, 221000, China.
Bo NingDepartment of Otolaryngology-Hand and Neck Surgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, No.199, Jiefang South Road, Xuzhou, 221000, China.
Bing LiuDepartment of Otolaryngology-Hand and Neck Surgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, No.199, Jiefang South Road, Xuzhou, 221000, China.
Liangjun ChengDepartment of Otolaryngology-Hand and Neck Surgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, No.199, Jiefang South Road, Xuzhou, 221000, China.
Huachao LiDepartment of Otolaryngology-Hand and Neck Surgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, No.199, Jiefang South Road, Xuzhou, 221000, China.
Mei MaDepartment of Otolaryngology-Hand and Neck Surgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, The Xuzhou Clinical College of Xuzhou Medical University, No.199, Jiefang South Road, Xuzhou, 221000, China. mmstmay@126.com.ORCID http://orcid.org/0009-0008-0760-3505

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAcquired middle ear cholesteatomas (AMECs) is a pathological condition characterized by abnormal epithelial cell proliferation in the middle ear, often resulting from retraction pocket and epithelial migration theories. The aim of this study was to find the abnormal expressed circular RNAs (circ_RNAs) in AMECs and explore their role in the inflammatory response of AMECs.

methodsThirty-two AMECs patients and 32 healthy volunteers were recruited. Expression levels of circ_RNAs and inflammatory genes were quantified via reverse transcription quantitative polymerase chain reaction. Concentrations of inflammatory cytokines in human AMECs or normal post-auricular skin samples were measured using enzyme-linked immunosorbent assay.

resultsResults showed that circ_0006168 was higher expressed in AMECs. Receiver operating characteristic (ROC) curve analysis indicated that circ_0006168 might serve as a sensitive biomarker for diagnosing AMECs. Besides, AMECs samples showed increased inflammatory cytokines concentrations. Thirty-two AMECs patients were divided into the High (N = 17) and Low (N = 15) groups according to the expression of circ_0006168. The High group patients had more tinnitus and severe hearing loss than the Low group.

conclusionIn summary, our findings suggested that circ_0006168 exacerbated inflammatory responses in AMECs, suggesting that circ_0006168 might be a potential biomarker in AMECs.

Indexed as

Cholesteatoma, Middle EarRNA, CircularAdultBiomarkersCase-Control StudiesCytokinesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedROC CurveYoung AdultBiomarkersCytokinesRNA, CircularAcquired middle ear cholesteatomasCirc_0006168CytokinesInflammatory response

Identifiers

PMID40220186

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.