Monitoring Dynamic of cAMP Signaling in Primary Murine CD4

Roberta Kurelić, Marie Bielenberg, Viacheslav O Nikolaev

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roberta KurelićInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Marie BielenbergInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Viacheslav O NikolaevInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3',5'-Cyclic adenosine monophosphate (cAMP) is a second messenger with diverse actions and strong immunomodulatory effects. For example, in T cells, cAMP regulates a myriad of functional responses ranging from peripheral maintenance of naïve T cells and their activation via T cell receptors to the execution of effector functions. cAMP level in the cell is regulated by adenylyl cyclases (ACs) and phosphodiesterases (PDEs). While ACs get activated after stimulation of G-protein coupled receptors on the surface of CD4

Indexed as

CD4-Positive T-LymphocytesCyclic AMPFluorescence Resonance Energy TransferSignal TransductionAdenylyl CyclasesAnimalsGuanine Nucleotide Exchange FactorsLymphocyte ActivationMiceMice, TransgenicPhosphoric Diester HydrolasesAdenylyl CyclasesCyclic AMPEpac protein, mouseGuanine Nucleotide Exchange FactorsPhosphoric Diester HydrolasescAMPCD4+ T cellsFRETFRET biosensorsT cell activationTransgenic mice

Identifiers

PMID40220229

DOI10.1007/978-1-4939-2537-7_9

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.