ArticleDiscover oncology2025
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeLiver cancer, also known as hepatocellular carcinoma (HCC), is one of the most prevalent and lethal malignancies in the world. The management of HCC depends on the underlying hepatic function and histological stage of the neoplasm, potentially encompassing locoregional therapies, surgical resection, hepatic transplantation, targeted drug therapies, and immunotherapy. However, the outlook for advanced HCC remains poor, with global 5-year survival rates below 15%. Consequently, it is imperative to identify novel tumor biomarkers for HCC prediction.
methodsMultiple public databases were used to analyze PTBP2 expression, potential biological functions, and immune infiltration levels in HCC. In addition, immunohistochemical staining, phenotypic experiments, flow cytometry, and mouse subcutaneous tumors were used to verify the elevated PTBP2 expression and its oncogenic effect in HCC.
resultsThe expression of PTBP2 is abnormally high in liver cancer and promoted the occurrence and development of HCC.
conclusionsOur study demonstrated that HCC tissues exhibited increased levels of PTBP2 expression compared to normal liver tissues. Elevated PTBP2 expression has been identified as closely linked to low survival in patients with HCC and could be a clinically independent prognostic factor. Additionally, PTBP2 may influence the development and forecasting of patients with HCC by altering the TME. Moreover, we confirmed the association between PTBP2 expression and HCC, both in vivo and in vitro.
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