Evidence map›Paper›PMID 40220296›Full record

ArticleCell reports2025

SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19.

Marine Barthez, Biyun Xue, Jian Zheng, Yifei Wang, Zehan Song, Wei-Chieh Mu, Chih-Ling Wang, Jiayue Guo, Fanghan Yang, Yuze Ma and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. NADThe Journal of general virology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. SIRT2 and NADAging cell · 2025
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marine BarthezDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Biyun XueDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Jian ZhengDepartment of Microbiology and Immunology, Center for Predictive Medicine, University of Louisville, Louisville, KY, USA.
Yifei WangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
Zehan SongDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
Wei-Chieh MuDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
Chih-Ling WangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jiayue GuoDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Fanghan YangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
Yuze MaDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Xuetong WeiDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
Chengjin YeTexas Biomedical Research Institute, San Antonio, TX, USA.
Nicholas SimsDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Luis Martinez-SobridoTexas Biomedical Research Institute, San Antonio, TX, USA.
Stanley PerlmanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA; Department of Pediatrics, University of Iowa, Iowa City, IA, USA. Electronic address: stanley-perlman@uiowa.edu.
Danica ChenDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA; Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: danicac@berkeley.edu.

Funding

SARS-CoV Proteins in Heterologous Viral InfectionP01AI060699 · NIAID · UNIVERSITY OF IOWA · PI PERLMAN, STANLEY · 2004 to 2021
$21.5M
Role of eicosanoids in pathogenic human CoV infectionsR01AI129269 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 2016 to 2026
$4.7M
Inflammation and Aging-associated DiabetesR01AG063389 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2019 to 2023
$2.0M
Nutrient Sensing, Hematopoietic Stem Cell Metabolism and AgingR01AG063404 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2022
$2.0M
Hematopoietic Stem Cell AgingR01DK117481 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2021
$1.7M
Neural Stem Cell Aging and NeurodegenerationR01AG082105 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DANICA CHEN · 2024 to 2026
$1.7M
NIAID NIH HHS P01 AI060699NIAID NIH HHS R01 AI129269NIA NIH HHS R01 AG063389NIA NIH HHS R01 AG063404NIA NIH HHS R01 AG082105NIDDK NIH HHS R01 DK117481
6 · The paper itself

Abstract

Aging-associated vulnerability to coronavirus disease 2019 (COVID-19) remains poorly understood. Here, we show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected aged mice lacking SIRT2, a cytosolic NAD

Indexed as

AgingCOVID-19NucleotidyltransferasesSirtuin 2AcetylationAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialHumansInflammationMaleMiceMice, Inbred C57BLMice, KnockoutNADSARS-CoV-2cGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialNADNucleotidyltransferasesSirt2 protein, mouseSirtuin 2agingcGASCOVID-19CP: ImmunologyCP: MicrobiologyinflammationmitochondriaNADORF3aSARS-CoV-2SIRT1SIRT2SIRT3SIRT6SIRT7sirtuin

Identifiers

PMID40220296
PMCPMC12074670

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.