ArticleCurrent biology : CB2025
Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.
Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Frogs Uncouple Neural Activity From Oxygen Consumption After Hibernation.Acta physiologica (Oxford, England) · 2026Article
- Frogs uncouple neural activity from oxygen consumption after hibernation.bioRxiv : the preprint server for biology · 2026Article
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Abstract
Homeostasis is a driving principle in physiology. To achieve homeostatic control of neural activity, neurons monitor their activity levels and then initiate corrective adjustments in excitability when activity strays from a set point. However, fluctuations in the brain microenvironment, such as temperature, pH, and other ions, represent some of the most common perturbations to neural function in animals. Therefore, it is unclear whether activity sensing is a universal strategy for different types of perturbations or whether stability may arise by sensing specific environmental cues. Here, we show that the respiratory network of amphibians mounts a fast homeostatic response to restore motor function following inactivity caused by cooling over the physiological range. This response was not initiated by inactivity but rather by temperature. Compensation involved cold activation of noradrenergic neurons via mechanisms that relied, in part, on inhibition of the Na
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.