Evidence map›Paper›PMID 40221123›Full record

ArticleBiological psychology2025

Task-based neural correlates of self-focused attention associated with cognitive behavioral therapy response.

Emily M Iannazzi, Gillian Grennan, Yuchen Zhao, Kelly Chang, Jamie D Feusner, Sabine Wilhelm, Dara S Manoach, Angela Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emily M IannazziDepartment of Psychology, University of Washington, Seattle, WA 98195-1525, USA. Electronic address: eiann@uw.edu.
Gillian GrennanDepartment of Psychology, University of Washington, Seattle, WA 98195-1525, USA. Electronic address: eiann@uw.edu.
Yuchen ZhaoDepartment of Psychology, University of Washington, Seattle, WA 98195-1525, USA.
Kelly ChangDepartment of Psychology, University of Washington, Seattle, WA 98195-1525, USA.
Jamie D FeusnerCentre for Addiction and Mental Health, Brain Imaging Health Center, Ontario, Toronto M5T1R8, Canada; Department of Psychiatry, University of Toronto, Ontario, Toronto M5T1R8, Canada; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Sabine WilhelmDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2696, USA.
Dara S ManoachDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2696, USA; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129-2020, USA.
Angela FangDepartment of Psychology, University of Washington, Seattle, WA 98195-1525, USA.

Funding

Neural mechanisms of perceptual abnormalities and their malleability in bodydysmorphic disorderR01MH121520 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2020 to 2025
$2.8M
Contributions of Self-Focused Attention to Early Warning Indicators of CBT Non-ResponseR01MH133581 · NIMH · UNIVERSITY OF WASHINGTON · PI Angela Fang · 2024 to 2026
$2.3M
Brain Correlates of Self-Focused Processing as a Biomarker of Treatment ResponseK23MH109593 · NIMH · UNIVERSITY OF WASHINGTON · PI FANG, ANGELA · 2016 to 2020
$888k
Exogenous Modulation of Visual Perception And Connectivity in Body Dysmorphic Disorder (EMPAC-BDD)R21MH128815 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI FEUSNER, JAMIE · 2022 to 2023
$273k
NIMH NIH HHS K23 MH109593NIMH NIH HHS R01 MH121520NIMH NIH HHS R01 MH133581NIMH NIH HHS R21 MH128815
6 · The paper itself

Abstract

Self-focused attention (SFA), a form of self-referential processing, is maladaptive in various psychiatric disorders and may be associated with poor treatment response. This study examined SFA in individuals with social anxiety disorder (SAD) and body dysmorphic disorder (BDD), testing the hypothesis that SFA is associated with hyperactivity within default network (DN) regions and with treatment response during cognitive-behavioral therapy. Participants included 30 patients with primary SAD or BDD and 28 healthy controls, who displayed above average and below average scores (respectively) on the Public Self-Consciousness Scale, which measured trait SFA. SFA was also measured by a self-referential encoding task, which yielded both behavioral reaction time measures and task-related fMRI measures of SFA. Results indicated significantly longer reaction times at pre-treatment for self vs. other trials in patients compared to controls, with patients showing notable improvement post-treatment. Neuroimaging revealed greater activation in DN regions, including the medial prefrontal cortex, during self vs. other trials in all participants; however, there were no significant group differences at pre- or post-treatment, nor in the changes from pre- to post-treatment. Neural measures of SFA were significantly associated with treatment response, whereas behavioral measures were not. These findings suggest that activity in DN regions may serve as a transdiagnostic biomarker of maladaptive SFA that is associated with treatment response.

Indexed as

AttentionBody Dysmorphic DisordersCognitive Behavioral TherapyPhobia, SocialSelf ConceptAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleReaction TimeTreatment OutcomeYoung AdultCognitive behavioral therapyDefault networkFunctional neuroimagingSelf-focused attentionTransdiagnostic

Identifiers

PMID40221123
PMCPMC12321005

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.