Evidence map›Paper›PMID 40221628›Full record

ArticleCommunications biology2025

Particulate matter and co-occurring genetic risk induce oxidative stress and cardiac and brain Alzheimer's pathology.

Helen M Butler, Everette Keller, Marice McCrorey, Gizem Keceli, Colin K Combs, Rakez Kayed, Rajasekaran Namakkal-S, Nazareno Paolocci, Bethany Jacobs Wolf, Loren E Wold and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Helen M ButlerCollege of Graduate Studies, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0001-6230-178X
Everette KellerCollege of Medicine, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0009-0005-8991-120X
Marice McCroreyCollege of Graduate Studies, Medical University of South Carolina, Charleston, SC, USA.
Gizem KeceliDepartment of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Colin K CombsSchool of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Rakez KayedDepartment of Neurology, University of Texas Medical Branch, Galveston, TX, USA.ORCID http://orcid.org/0000-0001-6216-8640
Rajasekaran Namakkal-SDepartment of Pathology/Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nazareno PaolocciDepartment of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Bethany Jacobs WolfCollege of Medicine, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0002-7124-5158
Loren E WoldDepartment of Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-8155-0204
Federica Del MonteDepartment of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA. delmonte@musc.edu.ORCID http://orcid.org/0000-0001-9506-9665

Funding

Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0M
Cellular, Biochemical and Molecular Sciences Training Program: Developing the skills and expertise needed for a changing biomedical landscapeT32GM132055 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Amy D Bradshaw, John P O'Bryan · 2019 to 2026
$3.9M
MUSC IMSDT32GM152386 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE, RINKER, JENNIFER ANNE · 2024 to 2024
$460k
NIA NIH HHS R01 AG057046NIGMS NIH HHS T32 GM132055NIGMS NIH HHS T32 GM152386U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG057046
6 · The paper itself

Abstract

Amyloid-beta (Aβ) aggregates, an Alzheimer's disease (AD) pathological hallmark, extend beyond the brain to the heart of heart failure (HF) and AD patients. Being diseases of the elderly, increased prevalence is expected as the population ages. However, changes in the incidence and prevalence of dementia over the past decades, and the independent association of exposure to air particulate matter (PM) with poor cognitive function, adverse cardiovascular effects, and oxidative stress hint to the contribution of other factors beyond senescence. Therefore we evaluate whether, and by which mechanism(s), PM exposure affects heart and brain proteinopathy with/without genetic predisposition.AD-prone and control mice are exposed for three months to filtered air (FA) or concentrated ambient PM < 2.5μm in diameter (PM

Indexed as

Air PollutantsAlzheimer DiseaseBrainOxidative StressParticulate MatterAmyloid beta-PeptidesAnimalsDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHumansMaleMiceMyocardiumAir PollutantsAmyloid beta-PeptidesParticulate Matter

Identifiers

PMID40221628
PMCPMC11993720

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.