ArticleBMC veterinary research2025
Antibacterial effects of cinnamaldehyde and hesperitin on resistant Glaesserella parasuis by suppressing QseBC two-component system.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Citrus Flavonoids-Coated Biogenic Nanoparticles for ControllingACS applied bio materials · 2026Article
- Possible applicability of flavonoid hesperetin for the treatment of dental biofilm-formingJournal of oral biology and craniofacial researchArticle
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Authors and funding
9 authors.
Funding
Abstract
backgroundGlaesserella parasuis (G. parasuis) is one of the most important porcine pathogens causing Glässer's disease, and QseBC two-component system (TCS) is associated with various behaviors of G. parasuis. Our preliminary tests confirmed that plant-derived compounds cinnamaldehyde (CAL) and hesperitin (HES) exhibited promising antimicrobial activity against G. parasuis. Here, we further investigate the antimicrobial effects of CAL and HES on G. parasuis and the underlying mechanisms.
resultsWe observed that CAL and HES affected the morphology and physiology of G. parasuis based on the biofilm biomass, confocal laser scanning microscope (CLSM) assay, scanning electron microscope (SEM) assay, and conductivity determination as well as intracellular iron level measurement either used alone or in combination. Moreover, CAL and HES can inhibit QseBC TCS of G. parasuis by down-regulating the QseBC related genes and quenching the QseC protein based on quantitative reverse transcription polymerase chain reaction (qRT-PCR) and molecular docking and fluorescence quenching assay. In vivo study further evident that CAL and HES exhibited significant antimicrobial and anti-inflammatory activity on G. parasuis-infected mice.
conclusionsThese findings suggested that CAL and HES can exert antibacterial activity on resistant G. parasuis by targeting QseBC, and they may serve as the promising antimicrobial agents for the treatment of G. parasuis infection.
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