ArticleSleep health2025
Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank.
Article in Sleep health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep.bioRxiv : the preprint server for biology · 2026Article
- Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
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7 authors.
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Abstract
objectivesSleep is a complex behavior regulated by genetic and environmental factors impacting disease outcomes. However, the effect of multidimensional sleep encompassing several sleep dimensions on common diseases, specifically mental health disorders, has yet to be fully elucidated. Using the Mass General Brigham Biobank, we examined the association of multidimensional sleep with disease outcomes and investigated whether sleep behaviors modulate genetic predisposition to unfavorable sleep on mental health diseases.
methodsWe generated a Polygenic Sleep Health Score using previously identified single nucleotide polymorphisms and constructed a Sleep Lifestyle Index based on self-reported questions and electronic health records; tested their association; performed phenome-wide association analyses between these indexes and clinical phenotypes; and analyzed their interaction on prevalent mental health diseases. A total of 15,884 participants were included in the analysis (mean age 54.4; 58.6% female).
resultsThe Polygenic Sleep Health Score was associated with the Sleep Lifestyle Index (β=0.050, 95% CI=0.032, 0.068) and with 114 disease outcomes spanning 12 disease groups, including obesity, sleep, and substance use disease outcomes (p<3.3×10
conclusionsFavorable sleep behaviors and genetic predisposition to healthy sleep may independently protect against disease, underscoring the impact of multidimensional sleep on population health and the need for prevention strategies focused on healthy sleep habits.
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