ArticleChemistry & biodiversity2025
Phytochemical Investigation and Biological Evaluation of Disynaphia filifolia: A Novel Source of Tremetone in Asteraceae.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Chemical profiling and cytotoxic activity of the endophytic fungus Epicoccum sorghinum isolated from Disynaphia filifolia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Spatial Phylogenetics Reveals Endemism Hotspots and Conservation Priorities in Chinese Asteraceae.Ecology and evolution · 2025Article
- Phytochemical Investigation and Biological Evaluation of Disynaphia filifolia: A Novel Source of Tremetone in Asteraceae.Chemistry & biodiversity · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical investigation of Disynaphia filifolia (Hassl.) R.M. King & H. Rob. (Asteraceae) led to the isolation of eight compounds, with tremetone being the major metabolite recovered. Tremetone has been suggested as the toxic compound in Ageratina altissima and Isocoma pluriflora, two species of the Asteraceae family. Although D. filifolia is not classified as a toxic species, tremetone was identified as the major compound in the crude extract of this species, constituting approximately 21% of the total content. Furthermore, 22 compounds were annotated using dereplication techniques, ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry, and a molecular networking approach. Antiproliferative assays indicated that tremetone was weakly active against the human tumor cell lines tested, proving to be even more toxic to non-tumor cells compared to tumor cell lines. Moreover, the potential antioxidant and antibacterial activities of the crude extract and fractions of D. filifolia are reported herein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.