ArticleScientific reports2025
Clinicopathological characterization of non-guttata corneal endothelial dystrophy in Saudi patients with idiopathic endothelial failure.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Complete SLC4A11 Detection in Saudi Congenital Hereditary Endothelial Dystrophy: A Transmembrane Glycine Hotspot and a Recurrent Splice Donor Allele in Consanguineous Patients.International journal of molecular sciences · 2026Article
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5 authors.
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Abstract
Corneal endothelial cell dysfunction is a common cause of corneal decompensation in elderly. We describe a non-guttata corneal endothelial dystrophy with correlation of the clinical features to the histopathological and ultrastructural characteristics in a cohort of Saudi patients. A retrospective study of all consecutive cases of primary corneal decompensation in phakic eyes due to endothelial attenuation, in the absence of guttata is conducted. Patients were treated by either penetrating keratoplasty (PKP) or Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) as a primary procedure between 2002 and 2016. Clinical and demographic data were obtained through chart review and the histopathological data were collected by reviewing Descemet's membrane (DM) in the corneal tissue samples of the affected eyes. We included 17 eyes from 17 patients (10 females and 7 males), with a mean age of 67.17 ± 8.98 years. All patients were phakic, and decreased vision was the patients' main complaint at presentation. The pre-operative endothelial cell count was obtained in 3 eyes with a mean of 531.7 ± 309.5/mm
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