Evidence map›Paper›PMID 40223264›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2025

The Association between Childhood Trauma on Executive Functioning and Treatment Outcomes among Individuals with Methamphetamine Use Disorder.

Cheng-Tsung Lin, Tzu-Yun Wang, Tsung-Yu Tsai, Huai-Hsuan Tseng, Kao Chin Chen, I Hui Lee, Po See Chen, Yen Kuang Yang, Ru-Band Lu

Abstract read
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Linking the Supplementary Motor Network and Executive Function in Developing Brain.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng-Tsung LinDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0009-0002-4388-0493
Tzu-Yun WangDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-0561-9967
Tsung-Yu TsaiDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0003-4593-2904
Huai-Hsuan TsengDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-5213-1585
Kao Chin ChenDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-8091-8820
I Hui LeeDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0003-2970-5744
Po See ChenDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0003-4963-578X
Yen Kuang YangDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-9355-9636
Ru-Band LuDepartment of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-6411-3547

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Childhood trauma is associated with executive function impairment and an increased risk of methamphetamine (MA) use. MA use itself also compromises executive function. Limited evidence is known about the association between childhood trauma, executive functioning and treatment outcomes among individuals with MA use disorder (MAUD). The study explored whether patients with MAUD who had experienced childhood trauma presented poorer executive function and treatment outcomes. Methods: The participants were individuals with MAUD and were all recruited from an outpatient-based addiction clinic from 2019 to 2022. Childhood trauma was assessed using Childhood Trauma Questionnaire-Short Form. The Wisconsin Card Sorting Test (WCST), Severity of Dependence Scale (SDS), and Visual Analog Scale for Craving, and urine MA/amphetamine tests were assessed repeatedly during the one-year treatment program. Generalized estimating equations were used to estimate the changes in these outcomes. Results: In 115 MAUD patients we recruited those with a history of childhood physical neglect (PN) exhibited inferior WCST performance on number of categories completed ( Conclusion: Childhood trauma, particularly PN and SA, shows substantial adverse effects on executive function and treatment outcomes among MAUD patients.

Indexed as

Adverse childhood experiencesCravingExecutive functionMethamphetamineSubstance-related disorders

Identifiers

PMID40223264
PMCPMC12000665

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.