ArticleJournal of dental sciences2025
Bioactive materials for post-operative healing and pain relief following palatal epithelialized graft harvesting: A meta-analysis of randomized clinical trials.
Article in Journal of dental sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07458685 (Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft: a Randomized Controlled Clinical Trial
Who cites it
3 citing papers in PubMed.
- Comparative Evaluation of Soft Tissue Regeneration Rate Using Different Wound Closure Methods After Palatal Donor Site Harvesting: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Two-Step Palatal Shield Technique Using Flowable Composite Resin for Donor-Site Protection Following De-Epithelialized Free Gingival Grafting: A Case Report Illustrating a Novel Technique.Case reports in dentistry · 2026Article
- Clinical Applications and Efficacy of Cyanoacrylates in Oral Surgery and Periodontology: A Scoping Review.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/purpose: Palatal epithelial graft harvesting requires secondary healing, and various materials have been used to accelerate this and reduce discomfort. However, comparisons against standardized controls remain limited, especially in randomized clinical trials. This meta-analysis assessed the efficacy of bioactive materials of hyaluronic acid, platelet-rich fibrin, collagen, and cyanoacrylate in promoting healing and reducing pain after epithelial graft harvesting. Materials and methods: Clinical trials were identified from PubMed, Scopus, Web of Science and Embase up to August 2024. The efficacies of bioactive materials were assessed using Review Manager Analysis, with odds ratios calculated for complete wound healing and mean differences in Visual Analog Scale (VAS) scores for pain. Results: Of 787 references, 9 clinical trials met eligibility: 6 on healing and 7 on pain. Meta-analysis showed significant improvement in complete epithelialization for the overall materials vs. control (OR = 4.28). Subgroup analysis showed improvements for HA (OR = 4.80) and PRF (OR = 12.81), but not cyanoacrylate. Similar results were seen for VAS pain scores on days 1-3 and day 7, with benefits for the overall materials and individually for HA, PRF, and collagen, except cyanoacrylate. High heterogeneity was found on days 1-3 (I Conclusion: HA, PRF, and collagen may relief pain, and HA and PRF might aid healing after epithelialized gingival graft harvest (no trials recruited in evaluating the collagen's effect on wound healing). Cyanoacrylate may not support pain relief or healing. Further trials are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.