Evidence mapPaperPMID 40224418Full record

ReviewACS omega2025

Role of Phytonutrients in the Prevention and Treatment of Chronic Diseases: A Concrete Review.

Tabussam Tufail, Smeea Fatima, Huma Bader Ul Ain, Ali Ikram, Sana Noreen, Maksim Rebezov, Ammar Al-Farga, Rashad Saleh, Mohammad Ali Shariati

Abstract readReview
In one paragraph

Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Foods (Basel, Switzerland) · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Watercress (Life (Basel, Switzerland) · 2025
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tabussam TufailSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China.
Smeea FatimaUniversity Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, 54000, Pakistan.
Huma Bader Ul AinUniversity Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, 54000, Pakistan.
Ali IkramUniversity Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, 54000, Pakistan.
Sana NoreenUniversity Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, 54000, Pakistan.
Maksim RebezovDepartment of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, 26 Talalikhin Str., Moscow 109316, Russia.
Ammar Al-FargaDepartment of Biochemistry, College of Sciences, University of Jeddah, Jeddah, 21577, KSA.
Rashad SalehMedical Microbiology Department, Faculty of Science, IBB University, IBB, Yemen.ORCID https://orcid.org/0000-0003-4427-249X
Mohammad Ali ShariatiKazakh Research Institute of Processing and Food Industry (Semey Branch), Semey 071410, Kazakhstan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delving into the intricate role of phytonutrients is paramount to effectively preventing and treating chronic diseases. Phytonutrients are "plant-based nutrients" that positively affect human health. Phytonutrients perform primary therapeutic functions in the management and treatment of various diseases. It is reported that different types of pathogenesis occur due to the excessive production of oxidants (reactive nitrogen species and reactive oxygen species). The literature shows that a higher intake of fruits, vegetables, and other plant-based food is inversely related to treating different chronic diseases. Due to many phytonutrients (antioxidants) in fruits, vegetables, and other medicinal plants, they are considered major therapeutic agents for various diseases. The main purpose of this review is to summarize the major phytonutrients involved in preventing and treating diseases. Fourteen major phytonutrients are discussed in this review, such as polyphenols, anthocyanin, resveratrol, phytosterol (stigmasterol), flavonoids, isoflavonoids, limonoids, terpenoids, carotenoids, lycopene, quercetin, phytoestrogens, glucosinolates, and probiotics, which are well-known for their beneficial effects on the human body and treatment of different pathological conditions. It is concluded that phytonutrients play a major role in the prevention and treatment of diabetes mellitus, obesity, hypertension, cardiovascular disorders, other types of cancers, neurological disorders, age-related diseases, and inflammatory disorders and are also involved in various biological activities.

Identifiers

PMID40224418
PMCPMC11983219

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.