ArticleBrain circulation
Congestive heart failure and its associations with cognition and cerebral blood flow.
Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Potential role of meningeal lymphatic drainage in repetitive transcranial magnetic stimulation-induced cognitive improvement: A call for further research.World journal of psychiatry · 2025Article
- Role of prefrontal cortex in freezing of gait in Parkinson's disease: mechanisms and neuroimaging evidence.Frontiers in neurologyReview
- Surgical treatment for cognitive impairment caused by internal jugular vein stenosis: a clinical study of atlas transverse process resection.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCongestive heart failure (CHF) has been linked to dementia but for reasons not well understood. Our retrospective cohort study aims to determine if specific measures of CHF severity are associated with cognitive performance or cerebral blood flow velocity (CBFV) among decompensated CHF outpatients. MATERIALS AND
methodsOne hundred and thirty-eight patients with transthoracic echocardiogram ≤1-year preceding consent were included. Forty-nine patients had concurrent transcranial Doppler ultrasonography administered by a trained technician assessing anterior cerebral artery, middle cerebral artery, and internal carotid artery (ICA) CBFV. CHF characteristics considered were NYHA classification, CHF type (heart failure with preserved ejection fraction vs. heart failure with mildly reduced/reduced ejection fraction), and left ventricular ejection fraction (LVEF; continuous [per 5%] or categorized [≤40%, 40%-55%, and ≥55%]). A trained psychometrist administered a standardized cognitive battery including Rey Auditory Verbal Learning Test, Rey Complex Figure Copy and Immediate Recall test, Letter-Number Sequencing (LNS) test, and Trail Making Tests. Adjusted multivariable linear regression models determined the association between CHF characteristics and standardized cognitive tests as well as between CHF characteristics and standardized CBFV, in distinct models.
resultsOn average, NYHA Class 1-2 patients had better LNS scores than NYHA Class 3-4 patients (β: 0.47; 95% CI: 0.09, 0.84). Patients with LVEF 40%-55% had higher ICA CBFVs than those with LVEF ≤40% (β: 13.7; 95% CI: 1.01, 26.39). No associations between other CHF characteristics and either cognitive performance or CBFV were found.
conclusionBlood flow may be an important mechanism behind CHF-related cognitive decline, but studies with larger sample sizes and a control group without CHF are needed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.