Evidence map›Paper›PMID 40224709›Full record

ReviewIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2025

Anemia Management in Pediatric Chronic Kidney Disease: Current Challenges and Treatment Strategies.

Altaf Jamil, Barbara Gruner, Javairia Jamil, Alicia Bach, Tyler Severance, Kim Ebersol, Laura E Hesemann

Abstract readReview
In one paragraph

Review in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Altaf JamilDepartment of Pediatrics, Division of Hematology and Oncology, University of Missouri School of Medicine, Columbia, MO USA.ORCID 0009-0003-7659-1361
Barbara GrunerDepartment of Pediatrics, Division of Hematology and Oncology, University of Missouri School of Medicine, Columbia, MO USA.
Javairia JamilGulf Medical University, Thumbay University Hospital, Ajman, United Arab Emirates.
Alicia BachDepartment of Pediatrics, Division of Hematology and Oncology, University of Missouri School of Medicine, Columbia, MO USA.
Tyler SeveranceDepartment of Pediatrics, Division of Hematology and Oncology, University of Missouri School of Medicine, Columbia, MO USA.
Kim EbersolDepartment of Pediatrics, Division of Hematology and Oncology, University of Missouri School of Medicine, Columbia, MO USA.
Laura E HesemannDepartment of Pediatrics, Division of Nephrology, University of Missouri School of Medicine, Columbia, MO USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A prevalent complication of chronic kidney disease (CKD), iron deficiency anemia (IDA) continues to be underdiagnosed and undertreated. Anemia in CKD in children is associated with a reduced quality of life, and an increased morbidity and mortality. The multifaceted etiology of anemia in CKD involves factors such as diminished endogenous erythropoietin (EPO) production, absolute or functional iron deficiency, and heightened inflammation characterized by elevated hepcidin levels. This paper reviews the complexities of anemia management in pediatric CKD, emphasizing the pivotal role of iron supplementation and erythropoiesis-stimulating agents (ESAs) in ameliorating erythropoiesis and optimizing patient outcomes. While intravenous (IV) iron supplementation effectively addresses iron-restricted erythropoiesis and enhances ESA response, challenges persist in accurately defining anemia in pediatric CKD patients and establishing appropriate treatment targets.

Indexed as

AnemiaChronic kidney disease (CKD)Erythropoiesis-stimulating agent (ESA)Erythropoietin (EPO)HemoglobinIron deficiency anemia (IDA)Pediatric

Identifiers

PMID40224709
PMCPMC11992271

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.