Evidence map›Paper›PMID 40225162›Full record

ArticleHuman mutation2023

Frequency and Functional Characterization of

Nikolaj Juul Nitschke, Marwa Almosailleakh, Yiyuan Niu, Jakob Werner Hansen, Klas Raaschou-Jensen, Jakob Schmidt Jespersen, Marianne Tang Severinsen, Anne Stidsholt Roug, Morten Frödin, Joachim Lütken Weischenfeldt and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nikolaj Juul NitschkeDepartment of Hematology, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-4682-2371
Marwa AlmosailleakhDepartment of Hematology, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-6898-1365
Yiyuan NiuBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1195-0223
Jakob Werner HansenDepartment of Hematology, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-7315-3775
Klas Raaschou-JensenDepartment of Haematology, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-4032-6617
Jakob Schmidt JespersenBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4930-5900
Marianne Tang SeverinsenDepartment of Hematology, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0003-0996-1812
Anne Stidsholt RougDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-2621-5432
Morten FrödinBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3691-9820
Joachim Lütken WeischenfeldtBiotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mette Klarskov AndersenDepartment of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
Kirsten GrønbækDepartment of Hematology, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-1535-9601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current estimates suggest that up to 10% of patients with myeloid neoplasms (MN) harbor variants associated with a germline predisposition. A pathogenic variant in the runt-related transcription factor 1 gene (

Indexed as

Core Binding Factor Alpha 2 SubunitGerm-Line MutationLeukemia, Myeloid, AcuteMyeloproliferative DisordersAdolescentAdultAgedFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedCore Binding Factor Alpha 2 SubunitRUNX1 protein, human

Identifiers

PMID40225162
PMCPMC11919008

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.