Evidence map›Paper›PMID 40225282›Full record

ArticleScientifica2025

EGCG and Taxifolin Modulate Secretory Activity and Expression of Dentinogenesis Markers in Odontoblast-Like Cells.

Cristiane Duque, Rafaela Laruzo Rabelo, Gabriela Pacheco de Almeida Braga, Igor Paulino Mendes Soares, Maria Eduarda de Souza, Daniela Alvim Chrisostomo, Josimeri Hebling, Carlos Alberto de Souza Costa, Anuradha Prakki, Luís Octavio Regasini

Abstract read
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In one paragraph

Article in Scientifica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristiane DuqueUniversidade Católica Portuguesa (UCP), Faculty of Dental Medicine, Center for Interdisciplinary Research in Health (CIIS), Estrada da Circunvalação, s/n 3504-505, Viseu, Portugal.ORCID https://orcid.org/0000-0002-2575-279X
Rafaela Laruzo RabeloSão Paulo State University (UNESP), Department of Preventive and Restorative Dentistry, Araçatuba Dental School, R. José Bonifácio, 1193, Araçatuba 16015-050, Brazil.ORCID https://orcid.org/0000-0003-1104-9283
Gabriela Pacheco de Almeida BragaSão Paulo State University (UNESP), Department of Preventive and Restorative Dentistry, Araçatuba Dental School, R. José Bonifácio, 1193, Araçatuba 16015-050, Brazil.ORCID https://orcid.org/0000-0001-5004-7489
Igor Paulino Mendes SoaresSão Paulo State University (UNESP), Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, R. Humaitá, 1680, Araraquara 14801-385, Brazil.ORCID https://orcid.org/0000-0002-5748-5040
Maria Eduarda de SouzaSão Paulo State University (UNESP), Department of Preventive and Restorative Dentistry, Araçatuba Dental School, R. José Bonifácio, 1193, Araçatuba 16015-050, Brazil.
Daniela Alvim ChrisostomoSão Paulo State University (UNESP), Department of Preventive and Restorative Dentistry, Araçatuba Dental School, R. José Bonifácio, 1193, Araçatuba 16015-050, Brazil.ORCID https://orcid.org/0000-0003-0622-8236
Josimeri HeblingSão Paulo State University (UNESP), Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, Araraquara School of Dentistry, R. Humaitá, 1680, Araraquara 14801-385, Brazil.ORCID https://orcid.org/0000-0002-2846-2325
Carlos Alberto de Souza CostaSão Paulo State University (UNESP), Department of Physiology and Pathology, Araraquara School of Dentistry, R. Humaitá, 1680, Araraquara 14801-385, Brazil.ORCID https://orcid.org/0000-0002-7455-6867
Anuradha PrakkiUniversity of Toronto, Department of Clinical Sciences-Restorative Dentistry, Faculty of Dentistry, 124 Edward St, Toronto, Ontario M5G 1G6, Canada.ORCID https://orcid.org/0000-0002-8969-9043
Luís Octavio RegasiniSão Paulo State University (UNESP), Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities, and Exact Sciences, R. Cristóvão Colombo, 2265, 15054-000, São José do Rio Preto, Brazil.ORCID https://orcid.org/0000-0002-3705-0971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Odontoblasts are cells specialized in dentin matrix deposition and the first line of defense when the dentin-pulp complex is injured by pathological processes, such as dental caries and trauma. Natural compounds, such as flavonoids, could be useful to stimulate odontoblast activity and reparative dentinogenesis in vital pulp therapies, especially in immature permanent teeth. This study evaluated the effect of flavonoids on odontoblast secretory activity and the expression of dentinogenesis markers. The effect of flavonoids was evaluated on phenotypic mineralization markers (alkaline phosphatase (ALP) activity and mineralized nodule deposition) by colorimetric assays and on the expression of

Indexed as

alkaline phosphatasecytotoxicitydentin mineralizationflavonoidsgene expression

Identifiers

PMID40225282
PMCPMC11986927

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.